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Parent-of-origin tumourigenesis is mediated by an essential imprinted modifier in SDHD-linked paragangliomas: SLC22A18 and CDKN1C are candidate tumour modifiers.
Hoekstra AS, Addie RD, Ras C, Seifar RM, Ruivenkamp CA, Briaire-de Bruijn IH, Hes FJ, Jansen JC, Corssmit EP, Corver WE, Morreau H, Bovée JV, Bayley JP, Devilee P. Hoekstra AS, et al. Among authors: seifar rm. Hum Mol Genet. 2016 Sep 1;25(17):3715-3728. doi: 10.1093/hmg/ddw218. Epub 2016 Jul 8. Hum Mol Genet. 2016. PMID: 27402879
Inactivation of SDH and FH cause loss of 5hmC and increased H3K9me3 in paraganglioma/pheochromocytoma and smooth muscle tumors.
Hoekstra AS, de Graaff MA, Briaire-de Bruijn IH, Ras C, Seifar RM, van Minderhout I, Cornelisse CJ, Hogendoorn PC, Breuning MH, Suijker J, Korpershoek E, Kunst HP, Frizzell N, Devilee P, Bayley JP, Bovée JV. Hoekstra AS, et al. Among authors: seifar rm. Oncotarget. 2015 Nov 17;6(36):38777-88. doi: 10.18632/oncotarget.6091. Oncotarget. 2015. PMID: 26472283 Free PMC article.
Quantitative metabolomics using ID-MS.
Wahl SA, Seifar RM, Ten Pierick A, Ras C, van Dam JC, Heijnen JJ, van Gulik WM. Wahl SA, et al. Among authors: seifar rm. Methods Mol Biol. 2014;1191:91-105. doi: 10.1007/978-1-4939-1170-7_6. Methods Mol Biol. 2014. PMID: 25178786
An alternative, arginase-independent pathway for arginine metabolism in Kluyveromyces lactis involves guanidinobutyrase as a key enzyme.
Romagnoli G, Verhoeven MD, Mans R, Fleury Rey Y, Bel-Rhlid R, van den Broek M, Seifar RM, Ten Pierick A, Thompson M, Müller V, Wahl SA, Pronk JT, Daran JM. Romagnoli G, et al. Among authors: seifar rm. Mol Microbiol. 2014 Jul;93(2):369-89. doi: 10.1111/mmi.12666. Epub 2014 Jun 23. Mol Microbiol. 2014. PMID: 24912400 Free PMC article.
20 results