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Increased levels of a mycophenolic acid metabolite in patients with kidney failure negatively affect cardiomyocyte health.
Harlacher E, Schulte C, Vondenhoff S, Schmitt-Kopplin P, Diederich P, Hemmers C, Moellmann J, Wollenhaupt J, Veltrop R, Biessen E, Lehrke M, Peters B, Schlieper G, Kuppe C, Floege J, Jankowski V, Marx N, Jankowski J, Noels H. Harlacher E, et al. Among authors: lehrke m. Front Cardiovasc Med. 2024 Mar 6;11:1346475. doi: 10.3389/fcvm.2024.1346475. eCollection 2024. Front Cardiovasc Med. 2024. PMID: 38510194 Free PMC article.
2,8-Dihydroxyadenine-induced nephropathy causes hexosylceramide accumulation with increased mTOR signaling, reduced levels of protective SirT3 expression and impaired renal mitochondrial function.
Moellmann J, Krueger K, Wong DWL, Klinkhammer BM, Buhl EM, Dehairs J, Swinnen JV, Noels H, Jankowski J, Lebherz C, Boor P, Marx N, Lehrke M. Moellmann J, et al. Among authors: lehrke m. Biochim Biophys Acta Mol Basis Dis. 2024 Jan;1870(1):166825. doi: 10.1016/j.bbadis.2023.166825. Epub 2023 Aug 1. Biochim Biophys Acta Mol Basis Dis. 2024. PMID: 37536502 Free article.
Mapping cardiac remodeling in chronic kidney disease.
Kaesler N, Cheng M, Nagai J, O'Sullivan J, Peisker F, Bindels EMJ, Babler A, Moellmann J, Droste P, Franciosa G, Dugourd A, Saez-Rodriguez J, Neuss S, Lehrke M, Boor P, Goettsch C, Olsen JV, Speer T, Lu TS, Lim K, Floege J, Denby L, Costa I, Kramann R. Kaesler N, et al. Among authors: lehrke m. Sci Adv. 2023 Nov 24;9(47):eadj4846. doi: 10.1126/sciadv.adj4846. Epub 2023 Nov 24. Sci Adv. 2023. PMID: 38000021 Free PMC article.
Diabetes Mellitus and Heart Failure.
Lehrke M, Marx N. Lehrke M, et al. Am J Med. 2017 Jun;130(6S):S40-S50. doi: 10.1016/j.amjmed.2017.04.010. Am J Med. 2017. PMID: 28526183 Free article. Review.
Diabetes Mellitus and Heart Failure.
Lehrke M, Marx N. Lehrke M, et al. Am J Cardiol. 2017 Jul 1;120(1S):S37-S47. doi: 10.1016/j.amjcard.2017.05.014. Epub 2017 May 30. Am J Cardiol. 2017. PMID: 28606342 Free article. Review.
143 results