Freisheim JH - Search Results

1

Inhibition of mammalian folylpolyglutamate synthetase and human dihydrofolate reductase by 5,8-dideaza analogues of folic acid and aminopterin bearing a terminal L-ornithine.

Patil SA, Shane B, Freisheim JH, Singh SK, Hynes JB. Patil SA, et al. Among authors: freisheim jh. J Med Chem. 1989 Jul;32(7):1559-65. doi: 10.1021/jm00127a026. J Med Chem. 1989. PMID: 2738891

2

Inhibition of murine thymidylate synthase and human dihydrofolate reductase by 5,8-dideaza analogues of folic acid and aminopterin.

Hynes JB, Patil SA, Tomazic A, Kumar A, Pathak A, Tan XH, Li XQ, Ratnam M, Delcamp TJ, Freisheim JH. Hynes JB, et al. Among authors: freisheim jh. J Med Chem. 1988 Feb;31(2):449-54. doi: 10.1021/jm00397a031. J Med Chem. 1988. PMID: 3339615

3

Chemistry and antitumor evaluation of selected classical 2,4-diaminoquinazoline analogues of folic acid.

Hynes JB, Harmon SJ, Floyd GG, Farrington M, Hart LD, Gale GR, Washtien WL, Susten SS, Freisheim JH. Hynes JB, et al. Among authors: freisheim jh. J Med Chem. 1985 Feb;28(2):209-15. doi: 10.1021/jm00380a011. J Med Chem. 1985. PMID: 3968685

4

Synthesis and preliminary biological evaluation of analogues of 5,8-dideazaisofolic acid and its 2-desamino-2-methyl derivative containing fluorine at position five.

Hynes JB, Fetzer OS, Shane B, Freisheim JH. Hynes JB, et al. Among authors: freisheim jh. Adv Exp Med Biol. 1993;338:413-5. doi: 10.1007/978-1-4615-2960-6_82. Adv Exp Med Biol. 1993. PMID: 8304147 No abstract available.

5

Synthesis and biological evaluation of analogues of 5,8-dideazaisofolic acid (IAHQ) modified at positions 2, 4 and 9.

Hynes JB, Hagan RL, Shane B, Freisheim JH. Hynes JB, et al. Among authors: freisheim jh. Adv Exp Med Biol. 1993;338:417-20. doi: 10.1007/978-1-4615-2960-6_83. Adv Exp Med Biol. 1993. PMID: 8304148 No abstract available.

6

Quinazolines as inhibitors of dihydrofolate reductase. 3. Analogs of pteroic and isopteroic acids.

Hynes JB, Buck JM, D'Souza L, Freisheim JH. Hynes JB, et al. Among authors: freisheim jh. J Med Chem. 1975 Dec;18(12):1191-4. doi: 10.1021/jm00246a004. J Med Chem. 1975. PMID: 811798

7

Synthesis and biological evaluation of 5-deazaisofolic acid, 5-deaza-5,6,7,8-tetrahydroisofolic acid, and their N9-substituted analogues.

Singh SK, Dev IK, Duch DS, Ferone R, Smith GK, Freisheim JH, Hynes JB. Singh SK, et al. Among authors: freisheim jh. J Med Chem. 1991 Feb;34(2):606-10. doi: 10.1021/jm00106a021. J Med Chem. 1991. PMID: 1995883

8

Studies on the mechanism of antitumor action of 2-desamino-2-methyl-5,8-dideazaisofolic acid.

Hagan RL, Duch DS, Smith GK, Hanlon MH, Shane B, Freisheim JH, Hynes JB. Hagan RL, et al. Among authors: freisheim jh. Biochem Pharmacol. 1991 Mar 1;41(5):781-7. doi: 10.1016/0006-2952(91)90081-f. Biochem Pharmacol. 1991. PMID: 1998533

9

Comparison of the biological effects of selected 5,8-dideazafolate analogues with their 2-desamino counterparts.

Hynes JB, Patil SA, Hagan RL, Cole A, Kohler W, Freisheim JH. Hynes JB, et al. Among authors: freisheim jh. J Med Chem. 1989 Apr;32(4):852-6. doi: 10.1021/jm00124a019. J Med Chem. 1989. PMID: 2704031

10

Purification and characterization of dihydrofolate reductase from soybean seedlings.

Ratnam S, Delcamp TJ, Hynes JB, Freisheim JH. Ratnam S, et al. Among authors: freisheim jh. Arch Biochem Biophys. 1987 Jun;255(2):279-89. doi: 10.1016/0003-9861(87)90395-x. Arch Biochem Biophys. 1987. PMID: 3109322

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