Zhou M - Search Results

1

Concentration-Response Modeling of ECG Data From Early-Phase Clinical Studies as an Alternative Clinical and Regulatory Approach to Assessing QT Risk - Experience From the Development Program of Lemborexant.

Murphy PJ, Yasuda S, Nakai K, Yoshinaga T, Hall N, Zhou M, Aluri J, Rege B, Moline M, Ferry J, Darpo B. Murphy PJ, et al. Among authors: zhou m. J Clin Pharmacol. 2017 Jan;57(1):96-104. doi: 10.1002/jcph.785. Epub 2016 Aug 4. J Clin Pharmacol. 2017. PMID: 27338807 Clinical Trial.

2

Results from the IQ-CSRC prospective study support replacement of the thorough QT study by QT assessment in the early clinical phase.

Darpo B, Benson C, Dota C, Ferber G, Garnett C, Green CL, Jarugula V, Johannesen L, Keirns J, Krudys K, Liu J, Ortemann-Renon C, Riley S, Sarapa N, Smith B, Stoltz RR, Zhou M, Stockbridge N. Darpo B, et al. Among authors: zhou m. Clin Pharmacol Ther. 2015 Apr;97(4):326-35. doi: 10.1002/cpt.60. Clin Pharmacol Ther. 2015. PMID: 25670536 Clinical Trial.

3

Can Bias Evaluation Provide Protection Against False-Negative Results in QT Studies Without a Positive Control Using Exposure-Response Analysis?

Ferber G, Zhou M, Dota C, Garnett C, Keirns J, Malik M, Stockbridge N, Darpo B. Ferber G, et al. Among authors: zhou m. J Clin Pharmacol. 2017 Jan;57(1):85-95. doi: 10.1002/jcph.779. Epub 2016 Jul 7. J Clin Pharmacol. 2017. PMID: 27271102

4

The use of beat-to-beat electrocardiogram analysis to distinguish QT/QTc interval changes caused by moxifloxacin from those caused by vardenafil.

Fossa AA, Langdon G, Couderc JP, Zhou M, Darpo B, Wilson F, Wallis R, Davis JD. Fossa AA, et al. Among authors: zhou m. Clin Pharmacol Ther. 2011 Sep;90(3):449-54. doi: 10.1038/clpt.2011.139. Epub 2011 Aug 3. Clin Pharmacol Ther. 2011. PMID: 21814193 Clinical Trial.

5

Improving the precision of QT measurements.

Darpo B, Fossa AA, Couderc JP, Zhou M, Schreyer A, Ticktin M, Zapesochny A. Darpo B, et al. Among authors: zhou m. Cardiol J. 2011;18(4):401-10. Cardiol J. 2011. PMID: 21769821 Free article. Clinical Trial.

6

Lomitapide at supratherapeutic plasma levels does not prolong the Qtc interval--results from a TQT study with moxifloxacin and ketoconazole.

Darpo B, Ferber G, Zhou M, Sumeray M, Sager P. Darpo B, et al. Among authors: zhou m. Ann Noninvasive Electrocardiol. 2013 Nov;18(6):577-89. doi: 10.1111/anec.12103. Epub 2013 Sep 30. Ann Noninvasive Electrocardiol. 2013. PMID: 24118671 Free PMC article. Clinical Trial.

7

Effect of lenvatinib (E7080) on the QTc interval: results from a thorough QT study in healthy volunteers.

Shumaker RC, Zhou M, Ren M, Fan J, Martinez G, Aluri J, Darpo B. Shumaker RC, et al. Among authors: zhou m. Cancer Chemother Pharmacol. 2014 Jun;73(6):1109-17. doi: 10.1007/s00280-014-2444-6. Cancer Chemother Pharmacol. 2014. PMID: 24658627 Clinical Trial.

8

Safety, pharmacokinetics, pharmacogenomics and QT concentration-effect modelling of the SirT1 inhibitor selisistat in healthy volunteers.

Westerberg G, Chiesa JA, Andersen CA, Diamanti D, Magnoni L, Pollio G, Darpo B, Zhou M. Westerberg G, et al. Among authors: zhou m. Br J Clin Pharmacol. 2015 Mar;79(3):477-91. doi: 10.1111/bcp.12513. Br J Clin Pharmacol. 2015. PMID: 25223836 Free PMC article. Clinical Trial.

9

Effect of ponesimod, a selective S1P1 receptor modulator, on the QT interval in healthy individuals.

Hoch M, Darpo B, Brossard P, Zhou M, Stoltz R, Dingemanse J. Hoch M, et al. Among authors: zhou m. Basic Clin Pharmacol Toxicol. 2015 May;116(5):429-37. doi: 10.1111/bcpt.12336. Epub 2014 Nov 8. Basic Clin Pharmacol Toxicol. 2015. PMID: 25287214 Free article. Clinical Trial.

10

Detection of QTc effects in small studies--implications for replacing the thorough QT study.

Ferber G, Zhou M, Darpo B. Ferber G, et al. Among authors: zhou m. Ann Noninvasive Electrocardiol. 2015 Jul;20(4):368-77. doi: 10.1111/anec.12227. Epub 2014 Nov 4. Ann Noninvasive Electrocardiol. 2015. PMID: 25367715 Free PMC article.

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