Massive expansion of regulatory T-cells following interleukin 2 treatment during a phase I-II dendritic cell-based immunotherapy of metastatic renal cancer.
Lemoine FM, Cherai M, Giverne C, Dimitri D, Rosenzwajg M, Trebeden-Negre H, Chaput N, Barrou B, Thioun N, Gattegnio B, Selles F, Six A, Azar N, Lotz JP, Buzyn A, Sibony M, Delcourt A, Boyer O, Herson S, Klatzmann D, Lacave R.
Lemoine FM, et al. Among authors: six a.
Int J Oncol. 2009 Sep;35(3):569-81. doi: 10.3892/ijo_00000368.
Int J Oncol. 2009.
PMID: 19639177
Clinical Trial.
Interestingly, these 2 patients had a more prolonged survival than the patients receiving 3 vaccinations. Importantly, a transient and massive increase of circulating natural regulatory T-cells (nTregs) was evidenced in 3 patients following IL-2 administration. Over …
Interestingly, these 2 patients had a more prolonged survival than the patients receiving 3 vaccinations. Importantly, a trans …