Reggio PH - Search Results

1

Chromenopyrazole, a Versatile Cannabinoid Scaffold with in Vivo Activity in a Model of Multiple Sclerosis.

Morales P, Gómez-Cañas M, Navarro G, Hurst DP, Carrillo-Salinas FJ, Lagartera L, Pazos R, Goya P, Reggio PH, Guaza C, Franco R, Fernández-Ruiz J, Jagerovic N. Morales P, et al. Among authors: reggio ph. J Med Chem. 2016 Jul 28;59(14):6753-6771. doi: 10.1021/acs.jmedchem.6b00397. Epub 2016 Jul 6. J Med Chem. 2016. PMID: 27309150 Free PMC article.

2

The importance of the orientation of the C9 substituent to cannabinoid activity.

Reggio PH, Greer KV, Cox SM. Reggio PH, et al. J Med Chem. 1989 Jul;32(7):1630-5. doi: 10.1021/jm00127a038. J Med Chem. 1989. PMID: 2738895

3

Characterization of a region of steric interference at the cannabinoid receptor using the active analog approach.

Reggio PH, Panu AM, Miles S. Reggio PH, et al. J Med Chem. 1993 Jun 11;36(12):1761-71. doi: 10.1021/jm00064a010. J Med Chem. 1993. PMID: 8510104

4

Synthesis and pharmacology of a very potent cannabinoid lacking a phenolic hydroxyl with high affinity for the CB2 receptor.

Huffman JW, Yu S, Showalter V, Abood ME, Wiley JL, Compton DR, Martin BR, Bramblett RD, Reggio PH. Huffman JW, et al. Among authors: reggio ph. J Med Chem. 1996 Sep 27;39(20):3875-7. doi: 10.1021/jm960394y. J Med Chem. 1996. PMID: 8831752 No abstract available.

5

Importance of the C-1 substituent in classical cannabinoids to CB2 receptor selectivity: synthesis and characterization of a series of O,2-propano-delta 8-tetrahydrocannabinol analogs.

Reggio PH, Wang T, Brown AE, Fleming DN, Seltzman HH, Griffin G, Pertwee RG, Compton DR, Abood ME, Martin BR. Reggio PH, et al. J Med Chem. 1997 Sep 26;40(20):3312-8. doi: 10.1021/jm970136g. J Med Chem. 1997. PMID: 9379452

6

Exploration of biologically relevant conformations of anandamide, 2-arachidonylglycerol, and their analogues using conformational memories.

Barnett-Norris J, Guarnieri F, Hurst DP, Reggio PH. Barnett-Norris J, et al. Among authors: reggio ph. J Med Chem. 1998 Nov 19;41(24):4861-72. doi: 10.1021/jm9803471. J Med Chem. 1998. PMID: 9822555

7

The bioactive conformation of aminoalkylindoles at the cannabinoid CB1 and CB2 receptors: insights gained from (E)- and (Z)-naphthylidene indenes.

Reggio PH, Basu-Dutt S, Barnett-Norris J, Castro MT, Hurst DP, Seltzman HH, Roche MJ, Gilliam AF, Thomas BF, Stevenson LA, Pertwee RG, Abood ME. Reggio PH, et al. J Med Chem. 1998 Dec 17;41(26):5177-87. doi: 10.1021/jm9801197. J Med Chem. 1998. PMID: 9857088

8

The difference between the CB(1) and CB(2) cannabinoid receptors at position 5.46 is crucial for the selectivity of WIN55212-2 for CB(2).

Song ZH, Slowey CA, Hurst DP, Reggio PH. Song ZH, et al. Among authors: reggio ph. Mol Pharmacol. 1999 Oct;56(4):834-40. Mol Pharmacol. 1999. PMID: 10496968

9

Conformational memories and the endocannabinoid binding site at the cannabinoid CB1 receptor.

Barnett-Norris J, Hurst DP, Lynch DL, Guarnieri F, Makriyannis A, Reggio PH. Barnett-Norris J, et al. Among authors: reggio ph. J Med Chem. 2002 Aug 15;45(17):3649-59. doi: 10.1021/jm0200761. J Med Chem. 2002. PMID: 12166938

10

N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A) interaction with LYS 3.28(192) is crucial for its inverse agonism at the cannabinoid CB1 receptor.

Hurst DP, Lynch DL, Barnett-Norris J, Hyatt SM, Seltzman HH, Zhong M, Song ZH, Nie J, Lewis D, Reggio PH. Hurst DP, et al. Among authors: reggio ph. Mol Pharmacol. 2002 Dec;62(6):1274-87. doi: 10.1124/mol.62.6.1274. Mol Pharmacol. 2002. PMID: 12435794

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