Wright DL - Search Results

1

Charged Propargyl-Linked Antifolates Reveal Mechanisms of Antifolate Resistance and Inhibit Trimethoprim-Resistant MRSA Strains Possessing Clinically Relevant Mutations.

Reeve SM, Scocchera E, Ferreira JJ, G-Dayanandan N, Keshipeddy S, Wright DL, Anderson AC. Reeve SM, et al. Among authors: wright dl. J Med Chem. 2016 Jul 14;59(13):6493-500. doi: 10.1021/acs.jmedchem.6b00688. Epub 2016 Jun 28. J Med Chem. 2016. PMID: 27308944 Free PMC article.

2

Structure-based approach to the development of potent and selective inhibitors of dihydrofolate reductase from cryptosporidium.

Bolstad DB, Bolstad ES, Frey KM, Wright DL, Anderson AC. Bolstad DB, et al. Among authors: wright dl. J Med Chem. 2008 Nov 13;51(21):6839-52. doi: 10.1021/jm8009124. Epub 2008 Oct 4. J Med Chem. 2008. PMID: 18834108 Free PMC article.

3

Synthetic and crystallographic studies of a new inhibitor series targeting Bacillus anthracis dihydrofolate reductase.

Beierlein JM, Frey KM, Bolstad DB, Pelphrey PM, Joska TM, Smith AE, Priestley ND, Wright DL, Anderson AC. Beierlein JM, et al. Among authors: wright dl. J Med Chem. 2008 Dec 11;51(23):7532-40. doi: 10.1021/jm800776a. J Med Chem. 2008. PMID: 19007108 Free PMC article.

4

Crystal structures of wild-type and mutant methicillin-resistant Staphylococcus aureus dihydrofolate reductase reveal an alternate conformation of NADPH that may be linked to trimethoprim resistance.

Frey KM, Liu J, Lombardo MN, Bolstad DB, Wright DL, Anderson AC. Frey KM, et al. Among authors: wright dl. J Mol Biol. 2009 Apr 17;387(5):1298-308. doi: 10.1016/j.jmb.2009.02.045. Epub 2009 Feb 26. J Mol Biol. 2009. PMID: 19249312 Free PMC article.

5

In vitro biological activity and structural analysis of 2,4-diamino-5-(2'-arylpropargyl)pyrimidine inhibitors of Candida albicans.

Paulsen JL, Liu J, Bolstad DB, Smith AE, Priestley ND, Wright DL, Anderson AC. Paulsen JL, et al. Among authors: wright dl. Bioorg Med Chem. 2009 Jul 15;17(14):4866-72. doi: 10.1016/j.bmc.2009.06.021. Epub 2009 Jun 17. Bioorg Med Chem. 2009. PMID: 19560363 Free PMC article.

6

Towards the understanding of resistance mechanisms in clinically isolated trimethoprim-resistant, methicillin-resistant Staphylococcus aureus dihydrofolate reductase.

Frey KM, Lombardo MN, Wright DL, Anderson AC. Frey KM, et al. Among authors: wright dl. J Struct Biol. 2010 Apr;170(1):93-7. doi: 10.1016/j.jsb.2009.12.011. Epub 2009 Dec 21. J Struct Biol. 2010. PMID: 20026215 Free PMC article.

7

Antifolate agents: a patent review (2006 - 2010).

Wright DL, Anderson AC. Wright DL, et al. Expert Opin Ther Pat. 2011 Sep;21(9):1293-308. doi: 10.1517/13543776.2011.587804. Epub 2011 May 27. Expert Opin Ther Pat. 2011. PMID: 21619471 Free PMC article. Review.

8

Toward new therapeutics for skin and soft tissue infections: propargyl-linked antifolates are potent inhibitors of MRSA and Streptococcus pyogenes.

Viswanathan K, Frey KM, Scocchera EW, Martin BD, Swain Iii PW, Alverson JB, Priestley ND, Anderson AC, Wright DL. Viswanathan K, et al. Among authors: wright dl. PLoS One. 2012;7(2):e29434. doi: 10.1371/journal.pone.0029434. Epub 2012 Feb 7. PLoS One. 2012. PMID: 22347365 Free PMC article.

9

Prospective screening of novel antibacterial inhibitors of dihydrofolate reductase for mutational resistance.

Frey KM, Viswanathan K, Wright DL, Anderson AC. Frey KM, et al. Among authors: wright dl. Antimicrob Agents Chemother. 2012 Jul;56(7):3556-62. doi: 10.1128/AAC.06263-11. Epub 2012 Apr 9. Antimicrob Agents Chemother. 2012. PMID: 22491688 Free PMC article.

10

Acetylenic linkers in lead compounds: a study of the stability of the propargyl-linked antifolates.

Zhou W, Viswanathan K, Hill D, Anderson AC, Wright DL. Zhou W, et al. Among authors: wright dl. Drug Metab Dispos. 2012 Oct;40(10):2002-8. doi: 10.1124/dmd.112.046870. Epub 2012 Jul 18. Drug Metab Dispos. 2012. PMID: 22815313 Free PMC article.

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