López-Otín C - Search Results

1

Lon protease: A key enzyme controlling mitochondrial bioenergetics in cancer.

Quirós PM, Bárcena C, López-Otín C. Quirós PM, et al. Mol Cell Oncol. 2014 Dec 31;1(4):e968505. doi: 10.4161/23723548.2014.968505. eCollection 2014 Oct-Dec. Mol Cell Oncol. 2014. PMID: 27308364 Free PMC article.

2

Premature aging in mice activates a systemic metabolic response involving autophagy induction.

Mariño G, Ugalde AP, Salvador-Montoliu N, Varela I, Quirós PM, Cadiñanos J, van der Pluijm I, Freije JM, López-Otín C. Mariño G, et al. Hum Mol Genet. 2008 Jul 15;17(14):2196-211. doi: 10.1093/hmg/ddn120. Epub 2008 Apr 28. Hum Mol Genet. 2008. PMID: 18443001

3

Metalloproteases and the degradome.

Ugalde AP, Ordóñez GR, Quirós PM, Puente XS, López-Otín C. Ugalde AP, et al. Methods Mol Biol. 2010;622:3-29. doi: 10.1007/978-1-60327-299-5_1. Methods Mol Biol. 2010. PMID: 20135273

4

Proteomic profiling of adipose tissue from Zmpste24-/- mice, a model of lipodystrophy and premature aging, reveals major changes in mitochondrial function and vimentin processing.

Peinado JR, Quirós PM, Pulido MR, Mariño G, Martínez-Chantar ML, Vázquez-Martínez R, Freije JM, López-Otín C, Malagón MM. Peinado JR, et al. Mol Cell Proteomics. 2011 Nov;10(11):M111.008094. doi: 10.1074/mcp.M111.008094. Epub 2011 Aug 9. Mol Cell Proteomics. 2011. PMID: 21828285 Free PMC article.

5

Splicing-directed therapy in a new mouse model of human accelerated aging.

Osorio FG, Navarro CL, Cadiñanos J, López-Mejía IC, Quirós PM, Bartoli C, Rivera J, Tazi J, Guzmán G, Varela I, Depetris D, de Carlos F, Cobo J, Andrés V, De Sandre-Giovannoli A, Freije JM, Lévy N, López-Otín C. Osorio FG, et al. Sci Transl Med. 2011 Oct 26;3(106):106ra107. doi: 10.1126/scitranslmed.3002847. Sci Transl Med. 2011. PMID: 22030750

6

Activation of AMP-activated protein kinase (AMPK) provides a metabolic barrier to reprogramming somatic cells into stem cells.

Vazquez-Martin A, Vellon L, Quirós PM, Cufí S, Ruiz de Galarreta E, Oliveras-Ferraros C, Martin AG, Martin-Castillo B, López-Otín C, Menendez JA. Vazquez-Martin A, et al. Cell Cycle. 2012 Mar 1;11(5):974-89. doi: 10.4161/cc.11.5.19450. Epub 2012 Mar 1. Cell Cycle. 2012. PMID: 22333578

7

Loss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in mice.

Quirós PM, Ramsay AJ, Sala D, Fernández-Vizarra E, Rodríguez F, Peinado JR, Fernández-García MS, Vega JA, Enríquez JA, Zorzano A, López-Otín C. Quirós PM, et al. EMBO J. 2012 May 2;31(9):2117-33. doi: 10.1038/emboj.2012.70. Epub 2012 Mar 20. EMBO J. 2012. PMID: 22433842 Free PMC article.

8

Nuclear lamina defects cause ATM-dependent NF-κB activation and link accelerated aging to a systemic inflammatory response.

Osorio FG, Bárcena C, Soria-Valles C, Ramsay AJ, de Carlos F, Cobo J, Fueyo A, Freije JM, López-Otín C. Osorio FG, et al. Genes Dev. 2012 Oct 15;26(20):2311-24. doi: 10.1101/gad.197954.112. Epub 2012 Sep 26. Genes Dev. 2012. PMID: 23019125 Free PMC article.

9

New roles for OMA1 metalloprotease: From mitochondrial proteostasis to metabolic homeostasis.

Quirós PM, Ramsay AJ, López-Otín C. Quirós PM, et al. Adipocyte. 2013 Jan 1;2(1):7-11. doi: 10.4161/adip.21999. Adipocyte. 2013. PMID: 23700547 Free PMC article.

10

Supercomplex assembly determines electron flux in the mitochondrial electron transport chain.

Lapuente-Brun E, Moreno-Loshuertos R, Acín-Pérez R, Latorre-Pellicer A, Colás C, Balsa E, Perales-Clemente E, Quirós PM, Calvo E, Rodríguez-Hernández MA, Navas P, Cruz R, Carracedo Á, López-Otín C, Pérez-Martos A, Fernández-Silva P, Fernández-Vizarra E, Enríquez JA. Lapuente-Brun E, et al. Science. 2013 Jun 28;340(6140):1567-70. doi: 10.1126/science.1230381. Science. 2013. PMID: 23812712

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