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Further molecular characterisation of the OVT73 transgenic sheep model of Huntington's disease identifies cortical aggregates.
Huntington's Disease Sheep Collaborative Research Group; Reid SJ, Patassini S, Handley RR, Rudiger SR, McLaughlan CJ, Osmand A, Jacobsen JC, Morton AJ, Weiss A, Waldvogel HJ, MacDonald ME, Gusella JF, Bawden CS, Faull RL, Snell RG. Huntington's Disease Sheep Collaborative Research Group, et al. Among authors: patassini s. J Huntingtons Dis. 2013;2(3):279-95. doi: 10.3233/JHD-130067. J Huntingtons Dis. 2013. PMID: 25062676
Metabolic disruption identified in the Huntington's disease transgenic sheep model.
Handley RR, Reid SJ, Patassini S, Rudiger SR, Obolonkin V, McLaughlan CJ, Jacobsen JC, Gusella JF, MacDonald ME, Waldvogel HJ, Bawden CS, Faull RL, Snell RG. Handley RR, et al. Among authors: patassini s. Sci Rep. 2016 Feb 11;6:20681. doi: 10.1038/srep20681. Sci Rep. 2016. PMID: 26864449 Free PMC article.
Graded perturbations of metabolism in multiple regions of human brain in Alzheimer's disease: Snapshot of a pervasive metabolic disorder.
Xu J, Begley P, Church SJ, Patassini S, Hollywood KA, Jüllig M, Curtis MA, Waldvogel HJ, Faull RL, Unwin RD, Cooper GJ. Xu J, et al. Among authors: patassini s. Biochim Biophys Acta. 2016 Jun;1862(6):1084-92. doi: 10.1016/j.bbadis.2016.03.001. Epub 2016 Mar 5. Biochim Biophys Acta. 2016. PMID: 26957286 Free PMC article.
Elevation of brain glucose and polyol-pathway intermediates with accompanying brain-copper deficiency in patients with Alzheimer's disease: metabolic basis for dementia.
Xu J, Begley P, Church SJ, Patassini S, McHarg S, Kureishy N, Hollywood KA, Waldvogel HJ, Liu H, Zhang S, Lin W, Herholz K, Turner C, Synek BJ, Curtis MA, Rivers-Auty J, Lawrence CB, Kellett KA, Hooper NM, Vardy ER, Wu D, Unwin RD, Faull RL, Dowsey AW, Cooper GJ. Xu J, et al. Among authors: patassini s. Sci Rep. 2016 Jun 9;6:27524. doi: 10.1038/srep27524. Sci Rep. 2016. PMID: 27276998 Free PMC article.
Brain urea increase is an early Huntington's disease pathogenic event observed in a prodromal transgenic sheep model and HD cases.
Handley RR, Reid SJ, Brauning R, Maclean P, Mears ER, Fourie I, Patassini S, Cooper GJS, Rudiger SR, McLaughlan CJ, Verma PJ, Gusella JF, MacDonald ME, Waldvogel HJ, Bawden CS, Faull RLM, Snell RG. Handley RR, et al. Among authors: patassini s. Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11293-E11302. doi: 10.1073/pnas.1711243115. Epub 2017 Dec 11. Proc Natl Acad Sci U S A. 2017. PMID: 29229845 Free PMC article.
38 results