Norman BH - Search Results

1

Identification of potent and selective retinoic acid receptor gamma (RARγ) antagonists for the treatment of osteoarthritis pain using structure based drug design.

Hughes NE, Bleisch TJ, Jones SA, Richardson TI, Doti RA, Wang Y, Stout SL, Durst GL, Chambers MG, Oskins JL, Lin C, Adams LA, Page TJ, Barr RJ, Zink RW, Osborne H, Montrose-Rafizadeh C, Norman BH. Hughes NE, et al. Among authors: norman bh. Bioorg Med Chem Lett. 2016 Jul 15;26(14):3274-3277. doi: 10.1016/j.bmcl.2016.05.056. Epub 2016 May 20. Bioorg Med Chem Lett. 2016. PMID: 27261179

2

Benzopyrans are selective estrogen receptor beta agonists with novel activity in models of benign prostatic hyperplasia.

Norman BH, Dodge JA, Richardson TI, Borromeo PS, Lugar CW, Jones SA, Chen K, Wang Y, Durst GL, Barr RJ, Montrose-Rafizadeh C, Osborne HE, Amos RM, Guo S, Boodhoo A, Krishnan V. Norman BH, et al. J Med Chem. 2006 Oct 19;49(21):6155-7. doi: 10.1021/jm060491j. J Med Chem. 2006. PMID: 17034120

3

Benzopyrans as selective estrogen receptor beta agonists (SERBAs). Part 2: structure-activity relationship studies on the benzopyran scaffold.

Richardson TI, Norman BH, Lugar CW, Jones SA, Wang Y, Durbin JD, Krishnan V, Dodge JA. Richardson TI, et al. Among authors: norman bh. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3570-4. doi: 10.1016/j.bmcl.2007.04.051. Epub 2007 Apr 25. Bioorg Med Chem Lett. 2007. PMID: 17485205

4

Benzopyrans as selective estrogen receptor beta agonists (SERBAs). Part 3: synthesis of cyclopentanone and cyclohexanone intermediates for C-ring modification.

Richardson TI, Dodge JA, Durst GL, Pfeifer LA, Shah J, Wang Y, Durbin JD, Krishnan V, Norman BH. Richardson TI, et al. Among authors: norman bh. Bioorg Med Chem Lett. 2007 Sep 1;17(17):4824-8. doi: 10.1016/j.bmcl.2007.06.052. Epub 2007 Jun 20. Bioorg Med Chem Lett. 2007. PMID: 17614275

5

Benzopyrans as selective estrogen receptor beta agonists (SERBAs). Part 4: functionalization of the benzopyran A-ring.

Norman BH, Richardson TI, Dodge JA, Pfeifer LA, Durst GL, Wang Y, Durbin JD, Krishnan V, Dinn SR, Liu S, Reilly JE, Ryter KT. Norman BH, et al. Bioorg Med Chem Lett. 2007 Sep 15;17(18):5082-5. doi: 10.1016/j.bmcl.2007.07.009. Epub 2007 Jul 13. Bioorg Med Chem Lett. 2007. PMID: 17662603

6

Benzopyrans as selective estrogen receptor beta agonists (SERBAs). Part 5: Combined A- and C-ring structure-activity relationship studies.

Richardson TI, Dodge JA, Wang Y, Durbin JD, Krishnan V, Norman BH. Richardson TI, et al. Among authors: norman bh. Bioorg Med Chem Lett. 2007 Oct 15;17(20):5563-6. doi: 10.1016/j.bmcl.2007.08.009. Epub 2007 Aug 11. Bioorg Med Chem Lett. 2007. PMID: 17804226

7

Novel Autotaxin Inhibitors for the Treatment of Osteoarthritis Pain: Lead Optimization via Structure-Based Drug Design.

Jones SB, Pfeifer LA, Bleisch TJ, Beauchamp TJ, Durbin JD, Klimkowski VJ, Hughes NE, Rito CJ, Dao Y, Gruber JM, Bui H, Chambers MG, Chandrasekhar S, Lin C, McCann DJ, Mudra DR, Oskins JL, Swearingen CA, Thirunavukkarasu K, Norman BH. Jones SB, et al. Among authors: norman bh. ACS Med Chem Lett. 2016 Aug 2;7(9):857-61. doi: 10.1021/acsmedchemlett.6b00207. eCollection 2016 Sep 8. ACS Med Chem Lett. 2016. PMID: 27660691 Free PMC article.

8

Identification and pharmacological characterization of a novel inhibitor of autotaxin in rodent models of joint pain.

Thirunavukkarasu K, Swearingen CA, Oskins JL, Lin C, Bui HH, Jones SB, Pfeifer LA, Norman BH, Mitchell PG, Chambers MG. Thirunavukkarasu K, et al. Among authors: norman bh. Osteoarthritis Cartilage. 2017 Jun;25(6):935-942. doi: 10.1016/j.joca.2016.09.006. Epub 2016 Sep 13. Osteoarthritis Cartilage. 2017. PMID: 27638130 Free article.

9

Discovery and Characterization of 2-Acylaminoimidazole Microsomal Prostaglandin E Synthase-1 Inhibitors.

Schiffler MA, Antonysamy S, Bhattachar SN, Campanale KM, Chandrasekhar S, Condon B, Desai PV, Fisher MJ, Groshong C, Harvey A, Hickey MJ, Hughes NE, Jones SA, Kim EJ, Kuklish SL, Luz JG, Norman BH, Rathmell RE, Rizzo JR, Seng TW, Thibodeaux SJ, Woods TA, York JS, Yu XP. Schiffler MA, et al. Among authors: norman bh. J Med Chem. 2016 Jan 14;59(1):194-205. doi: 10.1021/acs.jmedchem.5b01249. Epub 2015 Dec 18. J Med Chem. 2016. PMID: 26653180

10

Identification and Characterization of Novel Microsomal Prostaglandin E Synthase-1 Inhibitors for Analgesia.

Chandrasekhar S, Harvey AK, Yu XP, Chambers MG, Oskins JL, Lin C, Seng TW, Thibodeaux SJ, Norman BH, Hughes NE, Schiffler MA, Fisher MJ. Chandrasekhar S, et al. Among authors: norman bh. J Pharmacol Exp Ther. 2016 Mar;356(3):635-44. doi: 10.1124/jpet.115.228932. Epub 2016 Jan 6. J Pharmacol Exp Ther. 2016. PMID: 26740668

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