Gan L - Search Results

1

Critical data-based re-evaluation of minocycline as a putative specific microglia inhibitor.

Möller T, Bard F, Bhattacharya A, Biber K, Campbell B, Dale E, Eder C, Gan L, Garden GA, Hughes ZA, Pearse DD, Staal RG, Sayed FA, Wes PD, Boddeke HW. Möller T, et al. Among authors: gan l. Glia. 2016 Oct;64(10):1788-94. doi: 10.1002/glia.23007. Epub 2016 Jun 1. Glia. 2016. PMID: 27246804 Review.

2

CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease.

Cho SH, Sun B, Zhou Y, Kauppinen TM, Halabisky B, Wes P, Ransohoff RM, Gan L. Cho SH, et al. Among authors: gan l. J Biol Chem. 2011 Sep 16;286(37):32713-22. doi: 10.1074/jbc.M111.254268. Epub 2011 Jul 19. J Biol Chem. 2011. PMID: 21771791 Free PMC article.

3

SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1β.

Cho SH, Chen JA, Sayed F, Ward ME, Gao F, Nguyen TA, Krabbe G, Sohn PD, Lo I, Minami S, Devidze N, Zhou Y, Coppola G, Gan L. Cho SH, et al. Among authors: gan l. J Neurosci. 2015 Jan 14;35(2):807-18. doi: 10.1523/JNEUROSCI.2939-14.2015. J Neurosci. 2015. PMID: 25589773 Free PMC article.

4

Targeting microglia for the treatment of Alzheimer's Disease.

Wes PD, Sayed FA, Bard F, Gan L. Wes PD, et al. Among authors: gan l. Glia. 2016 Oct;64(10):1710-32. doi: 10.1002/glia.22988. Epub 2016 Apr 21. Glia. 2016. PMID: 27100611 Review.

5

Microglial NFκB-TNFα hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia.

Krabbe G, Minami SS, Etchegaray JI, Taneja P, Djukic B, Davalos D, Le D, Lo I, Zhan L, Reichert MC, Sayed F, Merlini M, Ward ME, Perry DC, Lee SE, Sias A, Parkhurst CN, Gan WB, Akassoglou K, Miller BL, Farese RV Jr, Gan L. Krabbe G, et al. Among authors: gan l, gan wb. Proc Natl Acad Sci U S A. 2017 May 9;114(19):5029-5034. doi: 10.1073/pnas.1700477114. Epub 2017 Apr 24. Proc Natl Acad Sci U S A. 2017. PMID: 28438992 Free PMC article.

6

TREM2 and Amyloid Beta: A Love-Hate Relationship.

Udeochu J, Sayed FA, Gan L. Udeochu J, et al. Among authors: gan l. Neuron. 2018 Mar 7;97(5):991-993. doi: 10.1016/j.neuron.2018.02.018. Neuron. 2018. PMID: 29518360 Free article.

7

Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy.

Sayed FA, Telpoukhovskaia M, Kodama L, Li Y, Zhou Y, Le D, Hauduc A, Ludwig C, Gao F, Clelland C, Zhan L, Cooper YA, Davalos D, Akassoglou K, Coppola G, Gan L. Sayed FA, et al. Among authors: gan l. Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):10172-10177. doi: 10.1073/pnas.1811411115. Epub 2018 Sep 19. Proc Natl Acad Sci U S A. 2018. PMID: 30232263 Free PMC article.

8

Proximal recolonization by self-renewing microglia re-establishes microglial homeostasis in the adult mouse brain.

Zhan L, Krabbe G, Du F, Jones I, Reichert MC, Telpoukhovskaia M, Kodama L, Wang C, Cho SH, Sayed F, Li Y, Le D, Zhou Y, Shen Y, West B, Gan L. Zhan L, et al. Among authors: gan l. PLoS Biol. 2019 Feb 8;17(2):e3000134. doi: 10.1371/journal.pbio.3000134. eCollection 2019 Feb. PLoS Biol. 2019. PMID: 30735499 Free PMC article.

9

Discovery of small molecules that normalize the transcriptome and enhance cysteine cathepsin activity in progranulin-deficient microglia.

Telpoukhovskaia MA, Liu K, Sayed FA, Etchegaray JI, Xie M, Zhan L, Li Y, Zhou Y, Le D, Bahr BA, Bogyo M, Ding S, Gan L. Telpoukhovskaia MA, et al. Among authors: gan l. Sci Rep. 2020 Aug 13;10(1):13688. doi: 10.1038/s41598-020-70534-9. Sci Rep. 2020. PMID: 32792571 Free PMC article.

10

Alzheimer risk-increasing TREM2 variant causes aberrant cortical synapse density and promotes network hyperexcitability in mouse models.

Das M, Mao W, Voskobiynyk Y, Necula D, Lew I, Petersen C, Zahn A, Yu GQ, Yu X, Smith N, Sayed FA, Gan L, Paz JT, Mucke L. Das M, et al. Among authors: gan l. Neurobiol Dis. 2023 Oct 1;186:106263. doi: 10.1016/j.nbd.2023.106263. Epub 2023 Aug 15. Neurobiol Dis. 2023. PMID: 37591465 Free PMC article.

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