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A MYC-aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer.
Nat Med. 2016 Jul;22(7):744-53. doi: 10.1038/nm.4107. Epub 2016 May 23.
Nat Med. 2016.
PMID: 27213815
Deregulated MYC expression induces dependence upon AMPK-related kinase 5.
Liu L, Ulbrich J, Müller J, Wüstefeld T, Aeberhard L, Kress TR, Muthalagu N, Rycak L, Rudalska R, Moll R, Kempa S, Zender L, Eilers M, Murphy DJ.
Liu L, et al. Among authors: rudalska r.
Nature. 2012 Mar 28;483(7391):608-12. doi: 10.1038/nature10927.
Nature. 2012.
PMID: 22460906
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In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer.
Rudalska R, Dauch D, Longerich T, McJunkin K, Wuestefeld T, Kang TW, Hohmeyer A, Pesic M, Leibold J, von Thun A, Schirmacher P, Zuber J, Weiss KH, Powers S, Malek NP, Eilers M, Sipos B, Lowe SW, Geffers R, Laufer S, Zender L.
Rudalska R, et al.
Nat Med. 2014 Oct;20(10):1138-46. doi: 10.1038/nm.3679. Epub 2014 Sep 14.
Nat Med. 2014.
PMID: 25216638
Free PMC article.
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LXRα activation and Raf inhibition trigger lethal lipotoxicity in liver cancer.
Rudalska R, Harbig J, Snaebjornsson MT, Klotz S, Zwirner S, Taranets L, Heinzmann F, Kronenberger T, Forster M, Cui W, D'Artista L, Einig E, Hinterleitner M, Schmitz W, Dylawerska A, Kang TW, Poso A, Rosenfeldt MT, Malek NP, Bitzer M, Laufer S, Pichler BJ, Popov N, Schulze A, Zender L, Dauch D.
Rudalska R, et al.
Nat Cancer. 2021 Feb;2(2):201-217. doi: 10.1038/s43018-020-00168-3. Epub 2021 Feb 15.
Nat Cancer. 2021.
PMID: 35122079
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Senescence surveillance of pre-malignant hepatocytes limits liver cancer development.
Kang TW, Yevsa T, Woller N, Hoenicke L, Wuestefeld T, Dauch D, Hohmeyer A, Gereke M, Rudalska R, Potapova A, Iken M, Vucur M, Weiss S, Heikenwalder M, Khan S, Gil J, Bruder D, Manns M, Schirmacher P, Tacke F, Ott M, Luedde T, Longerich T, Kubicka S, Zender L.
Kang TW, et al. Among authors: rudalska r.
Nature. 2011 Nov 9;479(7374):547-51. doi: 10.1038/nature10599.
Nature. 2011.
PMID: 22080947
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Exploiting lipotoxicity for the treatment of liver cancer.
Rudalska R, Zender L, Dauch D.
Rudalska R, et al.
Br J Cancer. 2021 Nov;125(11):1459-1461. doi: 10.1038/s41416-021-01479-7. Epub 2021 Jul 23.
Br J Cancer. 2021.
PMID: 34302061
Free PMC article.
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A Direct in vivo RNAi screen identifies MKK4 as a key regulator of liver regeneration.
Wuestefeld T, Pesic M, Rudalska R, Dauch D, Longerich T, Kang TW, Yevsa T, Heinzmann F, Hoenicke L, Hohmeyer A, Potapova A, Rittelmeier I, Jarek M, Geffers R, Scharfe M, Klawonn F, Schirmacher P, Malek NP, Ott M, Nordheim A, Vogel A, Manns MP, Zender L.
Wuestefeld T, et al. Among authors: rudalska r.
Cell. 2013 Apr 11;153(2):389-401. doi: 10.1016/j.cell.2013.03.026.
Cell. 2013.
PMID: 23582328
Free article.
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Development of Highly Potent and Selective Covalent FGFR4 Inhibitors Based on SNAr Electrophiles.
Schwarz M, Kurkunov M, Wittlinger F, Rudalska R, Wang G, Schwalm MP, Rasch A, Wagner B, Laufer SA, Knapp S, Dauch D, Gehringer M.
Schwarz M, et al. Among authors: rudalska r.
J Med Chem. 2024 Apr 25;67(8):6549-6569. doi: 10.1021/acs.jmedchem.3c02483. Epub 2024 Apr 11.
J Med Chem. 2024.
PMID: 38604131
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