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Phase I study of pemetrexed with sorafenib in advanced solid tumors.
Poklepovic A, Gordon S, Shafer DA, Roberts JD, Bose P, Geyer CE Jr, McGuire WP, Tombes MB, Shrader E, Strickler K, Quigley M, Wan W, Kmieciak M, Massey HD, Booth L, Moran RG, Dent P. Poklepovic A, et al. Oncotarget. 2016 Jul 5;7(27):42625-42638. doi: 10.18632/oncotarget.9434. Oncotarget. 2016. PMID: 27213589 Free PMC article. Clinical Trial.
Sorafenib and HDAC inhibitors synergize to kill CNS tumor cells.
Tang Y, Yacoub A, Hamed HA, Poklepovic A, Tye G, Grant S, Dent P. Tang Y, et al. Among authors: poklepovic a. Cancer Biol Ther. 2012 May;13(7):567-74. doi: 10.4161/cbt.19771. Epub 2012 May 1. Cancer Biol Ther. 2012. PMID: 22406992 Free PMC article.
Sorafenib and pemetrexed toxicity in cancer cells is mediated via SRC-ERK signaling.
Bareford MD, Hamed HA, Allegood J, Cruickshanks N, Poklepovic A, Park MA, Ogretmen B, Spiegel S, Grant S, Dent P. Bareford MD, et al. Among authors: poklepovic a. Cancer Biol Ther. 2012 Jul;13(9):793-803. doi: 10.4161/cbt.20562. Epub 2012 Jun 7. Cancer Biol Ther. 2012. PMID: 22673740 Free PMC article.
Phase I trial of bortezomib and dacarbazine in melanoma and soft tissue sarcoma.
Poklepovic A, Youssefian LE, Winning M, Birdsell CA, Crosby NA, Ramakrishnan V, Ernstoff MS, Roberts JD. Poklepovic A, et al. Invest New Drugs. 2013 Aug;31(4):937-42. doi: 10.1007/s10637-012-9913-8. Epub 2013 Jan 13. Invest New Drugs. 2013. PMID: 23315028 Free PMC article. Clinical Trial.
Histone deacetylase inhibitors restore toxic BH3 domain protein expression in anoikis-resistant mammary and brain cancer stem cells, thereby enhancing the response to anti-ERBB1/ERBB2 therapy.
Cruickshanks N, Hamed HA, Booth L, Tavallai S, Syed J, Sajithlal GB, Grant S, Poklepovic A, Dent P. Cruickshanks N, et al. Among authors: poklepovic a. Cancer Biol Ther. 2013 Oct 1;14(10):982-96. doi: 10.4161/cbt.26234. Epub 2013 Aug 22. Cancer Biol Ther. 2013. PMID: 24025251 Free PMC article.
108 results