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Sustained accumulation of prelamin A and depletion of lamin A/C both cause oxidative stress and mitochondrial dysfunction but induce different cell fates.
Sieprath T, Corne TD, Nooteboom M, Grootaert C, Rajkovic A, Buysschaert B, Robijns J, Broers JL, Ramaekers FC, Koopman WJ, Willems PH, De Vos WH. Sieprath T, et al. Among authors: corne td. Nucleus. 2015;6(3):236-46. doi: 10.1080/19491034.2015.1050568. Epub 2015 May 21. Nucleus. 2015. PMID: 25996284 Free PMC article.