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Page 1
Physiological restraint of Bak by Bcl-xL is essential for cell survival.
Lee EF, Grabow S, Chappaz S, Dewson G, Hockings C, Kluck RM, Debrincat MA, Gray DH, Witkowski MT, Evangelista M, Pettikiriarachchi A, Bouillet P, Lane RM, Czabotar PE, Colman PM, Smith BJ, Kile BT, Fairlie WD. Lee EF, et al. Among authors: chappaz s. Genes Dev. 2016 May 15;30(10):1240-50. doi: 10.1101/gad.279414.116. Epub 2016 May 19. Genes Dev. 2016. PMID: 27198225 Free PMC article.
Dicer1-mediated miRNA processing shapes the mRNA profile and function of murine platelets.
Rowley JW, Chappaz S, Corduan A, Chong MM, Campbell R, Khoury A, Manne BK, Wurtzel JG, Michael JV, Goldfinger LE, Mumaw MM, Nieman MT, Kile BT, Provost P, Weyrich AS. Rowley JW, et al. Among authors: chappaz s. Blood. 2016 Apr 7;127(14):1743-51. doi: 10.1182/blood-2015-07-661371. Epub 2016 Jan 14. Blood. 2016. PMID: 26773046 Free PMC article.
BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis.
McArthur K, Whitehead LW, Heddleston JM, Li L, Padman BS, Oorschot V, Geoghegan ND, Chappaz S, Davidson S, San Chin H, Lane RM, Dramicanin M, Saunders TL, Sugiana C, Lessene R, Osellame LD, Chew TL, Dewson G, Lazarou M, Ramm G, Lessene G, Ryan MT, Rogers KL, van Delft MF, Kile BT. McArthur K, et al. Among authors: chappaz s. Science. 2018 Feb 23;359(6378):eaao6047. doi: 10.1126/science.aao6047. Science. 2018. PMID: 29472455
VDAC2 enables BAX to mediate apoptosis and limit tumor development.
Chin HS, Li MX, Tan IKL, Ninnis RL, Reljic B, Scicluna K, Dagley LF, Sandow JJ, Kelly GL, Samson AL, Chappaz S, Khaw SL, Chang C, Morokoff A, Brinkmann K, Webb A, Hockings C, Hall CM, Kueh AJ, Ryan MT, Kluck RM, Bouillet P, Herold MJ, Gray DHD, Huang DCS, van Delft MF, Dewson G. Chin HS, et al. Among authors: chappaz s. Nat Commun. 2018 Nov 26;9(1):4976. doi: 10.1038/s41467-018-07309-4. Nat Commun. 2018. PMID: 30478310 Free PMC article.
An essential role for α4A-tubulin in platelet biogenesis.
Strassel C, Magiera MM, Dupuis A, Batzenschlager M, Hovasse A, Pleines I, Guéguen P, Eckly A, Moog S, Mallo L, Kimmerlin Q, Chappaz S, Strub JM, Kathiresan N, de la Salle H, Van Dorsselaer A, Ferec C, Py JY, Gachet C, Schaeffer-Reiss C, Kile BT, Janke C, Lanza F. Strassel C, et al. Among authors: chappaz s. Life Sci Alliance. 2019 Feb 13;2(1):e201900309. doi: 10.26508/lsa.201900309. Print 2019 Feb. Life Sci Alliance. 2019. PMID: 30760556 Free PMC article.
A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis.
van Delft MF, Chappaz S, Khakham Y, Bui CT, Debrincat MA, Lowes KN, Brouwer JM, Grohmann C, Sharp PP, Dagley LF, Li L, McArthur K, Luo MX, Chin HS, Fairlie WD, Lee EF, Segal D, Duflocq S, Lessene R, Bernard S, Peilleron L, Nguyen T, Miles C, Wan SS, Lane RM, Wardak A, Lackovic K, Colman PM, Sandow JJ, Webb AI, Czabotar PE, Dewson G, Watson KG, Huang DCS, Lessene G, Kile BT. van Delft MF, et al. Among authors: chappaz s. Nat Chem Biol. 2019 Nov;15(11):1057-1066. doi: 10.1038/s41589-019-0365-8. Epub 2019 Oct 7. Nat Chem Biol. 2019. PMID: 31591564
Connexin-Dependent Transfer of cGAMP to Phagocytes Modulates Antiviral Responses.
Pépin G, De Nardo D, Rootes CL, Ullah TR, Al-Asmari SS, Balka KR, Li HM, Quinn KM, Moghaddas F, Chappaz S, Kile BT, Morand EF, Masters SL, Stewart CR, Williams BRG, Gantier MP. Pépin G, et al. Among authors: chappaz s. mBio. 2020 Jan 28;11(1):e03187-19. doi: 10.1128/mBio.03187-19. mBio. 2020. PMID: 31992625 Free PMC article.
30 results