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Page 1
Increased Expression of miR-23a Mediates a Loss of Expression in the RAF Kinase Inhibitor Protein RKIP.
Hatzl S, Geiger O, Kuepper MK, Caraffini V, Seime T, Furlan T, Nussbaumer E, Wieser R, Pichler M, Scheideler M, Nowek K, Jongen-Lavrencic M, Quehenberger F, Wölfler A, Troppmair J, Sill H, Zebisch A. Hatzl S, et al. Among authors: caraffini v. Cancer Res. 2016 Jun 15;76(12):3644-54. doi: 10.1158/0008-5472.CAN-15-3049. Epub 2016 Apr 15. Cancer Res. 2016. PMID: 27197200 Free PMC article.
Loss of RAF kinase inhibitor protein is involved in myelomonocytic differentiation and aggravates RAS-driven myeloid leukemogenesis.
Caraffini V, Geiger O, Rosenberger A, Hatzl S, Perfler B, Berg JL, Lim C, Strobl H, Kashofer K, Schauer S, Beham-Schmid C, Hoefler G, Geissler K, Quehenberger F, Kolch W, Athineos D, Blyth K, Wölfler A, Sill H, Zebisch A. Caraffini V, et al. Haematologica. 2020 Jan 31;105(2):375-386. doi: 10.3324/haematol.2018.209650. Print 2020. Haematologica. 2020. PMID: 31097632 Free PMC article.
RAF Kinase Inhibitor Protein in Myeloid Leukemogenesis.
Zebisch A, Caraffini V, Sill H. Zebisch A, et al. Among authors: caraffini v. Int J Mol Sci. 2019 Nov 16;20(22):5756. doi: 10.3390/ijms20225756. Int J Mol Sci. 2019. PMID: 31744053 Free PMC article. Review.
EZH2 inactivation in RAS-driven myeloid neoplasms hyperactivates RAS-signaling and increases MEK inhibitor sensitivity.
Berg JL, Perfler B, Hatzl S, Uhl B, Reinisch A, Pregartner G, Berghold A, Penz T, Schuster M, Geissler K, Prokesch A, Müller-Tidow C, Hoefler G, Kashofer K, Wölfler A, Sill H, Caraffini V, Zebisch A. Berg JL, et al. Among authors: caraffini v. Leukemia. 2021 May;35(5):1521-1526. doi: 10.1038/s41375-021-01161-0. Epub 2021 Feb 15. Leukemia. 2021. PMID: 33589750 Free PMC article. No abstract available.
The renal lineage factor PAX8 controls oncogenic signalling in kidney cancer.
Patel SA, Hirosue S, Rodrigues P, Vojtasova E, Richardson EK, Ge J, Syafruddin SE, Speed A, Papachristou EK, Baker D, Clarke D, Purvis S, Wesolowski L, Dyas A, Castillon L, Caraffini V, Bihary D, Yong C, Harrison DJ, Stewart GD, Machiela MJ, Purdue MP, Chanock SJ, Warren AY, Samarajiwa SA, Carroll JS, Vanharanta S. Patel SA, et al. Among authors: caraffini v. Nature. 2022 Jun;606(7916):999-1006. doi: 10.1038/s41586-022-04809-8. Epub 2022 Jun 8. Nature. 2022. PMID: 35676472 Free PMC article.
HIRA loss transforms FH-deficient cells.
Valcarcel-Jimenez L, Rogerson C, Yong C, Schmidt C, Yang M, Cremades-Rodelgo M, Harle V, Offord V, Wong K, Mora A, Speed A, Caraffini V, Tran MGB, Maher ER, Stewart GD, Vanharanta S, Adams DJ, Frezza C. Valcarcel-Jimenez L, et al. Among authors: caraffini v. Sci Adv. 2022 Oct 21;8(42):eabq8297. doi: 10.1126/sciadv.abq8297. Epub 2022 Oct 21. Sci Adv. 2022. PMID: 36269833 Free PMC article.
The SWI/SNF complex member SMARCB1 supports lineage fidelity in kidney cancer.
Wesolowski L, Ge J, Castillon L, Sesia D, Dyas A, Hirosue S, Caraffini V, Warren AY, Rodrigues P, Ciriello G, Patel SA, Vanharanta S. Wesolowski L, et al. Among authors: caraffini v. iScience. 2023 Jul 13;26(8):107360. doi: 10.1016/j.isci.2023.107360. eCollection 2023 Aug 18. iScience. 2023. PMID: 37554444 Free PMC article.
Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression.
Sciacovelli M, Dugourd A, Jimenez LV, Yang M, Nikitopoulou E, Costa ASH, Tronci L, Caraffini V, Rodrigues P, Schmidt C, Ryan DG, Young T, Zecchini VR, Rossi SH, Massie C, Lohoff C, Masid M, Hatzimanikatis V, Kuppe C, Von Kriegsheim A, Kramann R, Gnanapragasam V, Warren AY, Stewart GD, Erez A, Vanharanta S, Saez-Rodriguez J, Frezza C. Sciacovelli M, et al. Among authors: caraffini v. Nat Commun. 2022 Dec 20;13(1):7830. doi: 10.1038/s41467-022-35036-4. Nat Commun. 2022. PMID: 36539415 Free PMC article.