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Page 1
Increased GVHD-related mortality with broad-spectrum antibiotic use after allogeneic hematopoietic stem cell transplantation in human patients and mice.
Shono Y, Docampo MD, Peled JU, Perobelli SM, Velardi E, Tsai JJ, Slingerland AE, Smith OM, Young LF, Gupta J, Lieberman SR, Jay HV, Ahr KF, Porosnicu Rodriguez KA, Xu K, Calarfiore M, Poeck H, Caballero S, Devlin SM, Rapaport F, Dudakov JA, Hanash AM, Gyurkocza B, Murphy GF, Gomes C, Liu C, Moss EL, Falconer SB, Bhatt AS, Taur Y, Pamer EG, van den Brink MRM, Jenq RR. Shono Y, et al. Among authors: young lf. Sci Transl Med. 2016 May 18;8(339):339ra71. doi: 10.1126/scitranslmed.aaf2311. Sci Transl Med. 2016. PMID: 27194729 Free PMC article.
Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation.
Jenq RR, Ubeda C, Taur Y, Menezes CC, Khanin R, Dudakov JA, Liu C, West ML, Singer NV, Equinda MJ, Gobourne A, Lipuma L, Young LF, Smith OM, Ghosh A, Hanash AM, Goldberg JD, Aoyama K, Blazar BR, Pamer EG, van den Brink MR. Jenq RR, et al. Among authors: young lf. J Exp Med. 2012 May 7;209(5):903-11. doi: 10.1084/jem.20112408. Epub 2012 Apr 30. J Exp Med. 2012. PMID: 22547653 Free PMC article.
Donor CD19 CAR T cells exert potent graft-versus-lymphoma activity with diminished graft-versus-host activity.
Ghosh A, Smith M, James SE, Davila ML, Velardi E, Argyropoulos KV, Gunset G, Perna F, Kreines FM, Levy ER, Lieberman S, Jay HV, Tuckett AZ, Zakrzewski JL, Tan L, Young LF, Takvorian K, Dudakov JA, Jenq RR, Hanash AM, Motta AC, Murphy GF, Liu C, Schietinger A, Sadelain M, van den Brink MR. Ghosh A, et al. Among authors: young lf. Nat Med. 2017 Feb;23(2):242-249. doi: 10.1038/nm.4258. Epub 2017 Jan 9. Nat Med. 2017. PMID: 28067900 Free PMC article.
Nrf2 regulates CD4+ T cell-induced acute graft-versus-host disease in mice.
Tsai JJ, Velardi E, Shono Y, Argyropoulos KV, Holland AM, Smith OM, Yim NL, Rao UK, Kreines FM, Lieberman SR, Young LF, Lazrak A, Youssef S, Fu YY, Liu C, Lezcano C, Murphy GF, Na IK, Jenq RR, Hanash AM, Dudakov JA, van den Brink MRM. Tsai JJ, et al. Among authors: young lf. Blood. 2018 Dec 27;132(26):2763-2774. doi: 10.1182/blood-2017-10-812941. Epub 2018 Oct 31. Blood. 2018. PMID: 30381375 Free PMC article.
Interleukin-22 drives endogenous thymic regeneration in mice.
Dudakov JA, Hanash AM, Jenq RR, Young LF, Ghosh A, Singer NV, West ML, Smith OM, Holland AM, Tsai JJ, Boyd RL, van den Brink MR. Dudakov JA, et al. Among authors: young lf. Science. 2012 Apr 6;336(6077):91-5. doi: 10.1126/science.1218004. Epub 2012 Mar 1. Science. 2012. PMID: 22383805 Free PMC article.
Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host disease.
Hanash AM, Dudakov JA, Hua G, O'Connor MH, Young LF, Singer NV, West ML, Jenq RR, Holland AM, Kappel LW, Ghosh A, Tsai JJ, Rao UK, Yim NL, Smith OM, Velardi E, Hawryluk EB, Murphy GF, Liu C, Fouser LA, Kolesnick R, Blazar BR, van den Brink MR. Hanash AM, et al. Among authors: young lf. Immunity. 2012 Aug 24;37(2):339-50. doi: 10.1016/j.immuni.2012.05.028. Immunity. 2012. PMID: 22921121 Free PMC article.
Nrf2 regulates haematopoietic stem cell function.
Tsai JJ, Dudakov JA, Takahashi K, Shieh JH, Velardi E, Holland AM, Singer NV, West ML, Smith OM, Young LF, Shono Y, Ghosh A, Hanash AM, Tran HT, Moore MA, van den Brink MR. Tsai JJ, et al. Among authors: young lf. Nat Cell Biol. 2013 Mar;15(3):309-16. doi: 10.1038/ncb2699. Epub 2013 Feb 24. Nat Cell Biol. 2013. PMID: 23434824 Free PMC article.
Adoptively transferred TRAIL+ T cells suppress GVHD and augment antitumor activity.
Ghosh A, Dogan Y, Moroz M, Holland AM, Yim NL, Rao UK, Young LF, Tannenbaum D, Masih D, Velardi E, Tsai JJ, Jenq RR, Penack O, Hanash AM, Smith OM, Piersanti K, Lezcano C, Murphy GF, Liu C, Palomba ML, Sauer MG, Sadelain M, Ponomarev V, van den Brink MR. Ghosh A, et al. Among authors: young lf. J Clin Invest. 2013 Jun;123(6):2654-62. doi: 10.1172/JCI66301. Epub 2013 May 15. J Clin Invest. 2013. PMID: 23676461 Free PMC article.
PLZF confers effector functions to donor T cells that preserve graft-versus-tumor effects while attenuating GVHD.
Ghosh A, Holland AM, Dogan Y, Yim NL, Rao UK, Young LF, West ML, Singer NV, Lee H, Na IK, Tsai JJ, Jenq RR, Penack O, Hanash AM, Lezcano C, Murphy GF, Liu C, Sadelain M, Sauer MG, Sant'angelo D, van den Brink MR. Ghosh A, et al. Among authors: young lf. Cancer Res. 2013 Aug 1;73(15):4687-96. doi: 10.1158/0008-5472.CAN-12-4699. Epub 2013 Jun 3. Cancer Res. 2013. PMID: 23733752 Free PMC article.
37 results