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The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia.
Brumatti G, Ma C, Lalaoui N, Nguyen NY, Navarro M, Tanzer MC, Richmond J, Ghisi M, Salmon JM, Silke N, Pomilio G, Glaser SP, de Valle E, Gugasyan R, Gurthridge MA, Condon SM, Johnstone RW, Lock R, Salvesen G, Wei A, Vaux DL, Ekert PG, Silke J. Brumatti G, et al. Among authors: ekert pg. Sci Transl Med. 2016 May 18;8(339):339ra69. doi: 10.1126/scitranslmed.aad3099. Sci Transl Med. 2016. PMID: 27194727
Apoptosis and the immune system.
Ekert PG, Vaux DL. Ekert PG, et al. Br Med Bull. 1997;53(3):591-603. doi: 10.1093/oxfordjournals.bmb.a011632. Br Med Bull. 1997. PMID: 9374039 Review.
Apoptosis, haemopoiesis and leukaemogenesis.
Ekert PG, Vaux DL. Ekert PG, et al. Baillieres Clin Haematol. 1997 Sep;10(3):561-76. doi: 10.1016/s0950-3536(97)80026-1. Baillieres Clin Haematol. 1997. PMID: 9421616 Review.
Caspase inhibitors.
Ekert PG, Silke J, Vaux DL. Ekert PG, et al. Cell Death Differ. 1999 Nov;6(11):1081-6. doi: 10.1038/sj.cdd.4400594. Cell Death Differ. 1999. PMID: 10578177 Review.
149 results