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Optimization of the phenylurea moiety in a phosphoinositide 3-kinase (PI3K) inhibitor to improve water solubility and the PK profile by introducing a solubilizing group and ortho substituents.
Kawada H, Ebiike H, Tsukazaki M, Yamamoto S, Koyama K, Nakamura M, Morikami K, Yoshinari K, Yoshida M, Ogawa K, Shimma N, Tsukuda T, Ohwada J. Kawada H, et al. Among authors: yamamoto s. Bioorg Med Chem. 2016 Jul 1;24(13):2897-2906. doi: 10.1016/j.bmc.2016.04.060. Epub 2016 Apr 28. Bioorg Med Chem. 2016. PMID: 27189888
CRISPR-Cas9-based photoactivatable transcription system.
Nihongaki Y, Yamamoto S, Kawano F, Suzuki H, Sato M. Nihongaki Y, et al. Among authors: yamamoto s. Chem Biol. 2015 Feb 19;22(2):169-74. doi: 10.1016/j.chembiol.2014.12.011. Epub 2015 Jan 22. Chem Biol. 2015. PMID: 25619936
Analysis of Inertial Measurement Unit Data for an AI-Based Physical Function Assessment System Using In-Clinic-like Movements.
Kouno N, Takahashi S, Takasawa K, Komatsu M, Ishiguro N, Takeda K, Matsuoka A, Fujimori M, Yokoyama K, Yamamoto S, Honma Y, Kato K, Obama K, Hamamoto R. Kouno N, et al. Among authors: yamamoto s. Bioengineering (Basel). 2024 Dec 5;11(12):1232. doi: 10.3390/bioengineering11121232. Bioengineering (Basel). 2024. PMID: 39768050 Free PMC article.
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