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Balancing drug resistance and growth rates via compensatory mutations in the Plasmodium falciparum chloroquine resistance transporter.
Petersen I, Gabryszewski SJ, Johnston GL, Dhingra SK, Ecker A, Lewis RE, de Almeida MJ, Straimer J, Henrich PP, Palatulan E, Johnson DJ, Coburn-Flynn O, Sanchez C, Lehane AM, Lanzer M, Fidock DA. Petersen I, et al. Among authors: dhingra sk. Mol Microbiol. 2015 Jul;97(2):381-95. doi: 10.1111/mmi.13035. Epub 2015 May 20. Mol Microbiol. 2015. PMID: 25898991 Free PMC article.
Adaptive evolution of malaria parasites in French Guiana: Reversal of chloroquine resistance by acquisition of a mutation in pfcrt.
Pelleau S, Moss EL, Dhingra SK, Volney B, Casteras J, Gabryszewski SJ, Volkman SK, Wirth DF, Legrand E, Fidock DA, Neafsey DE, Musset L. Pelleau S, et al. Among authors: dhingra sk. Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):11672-7. doi: 10.1073/pnas.1507142112. Epub 2015 Aug 10. Proc Natl Acad Sci U S A. 2015. PMID: 26261345 Free PMC article.
Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology.
Gabryszewski SJ, Dhingra SK, Combrinck JM, Lewis IA, Callaghan PS, Hassett MR, Siriwardana A, Henrich PP, Lee AH, Gnädig NF, Musset L, Llinás M, Egan TJ, Roepe PD, Fidock DA. Gabryszewski SJ, et al. Among authors: dhingra sk. PLoS Pathog. 2016 Nov 10;12(11):e1005976. doi: 10.1371/journal.ppat.1005976. eCollection 2016 Nov. PLoS Pathog. 2016. PMID: 27832198 Free PMC article.
Evidence for Regulation of Hemoglobin Metabolism and Intracellular Ionic Flux by the Plasmodium falciparum Chloroquine Resistance Transporter.
Lee AH, Dhingra SK, Lewis IA, Singh MK, Siriwardana A, Dalal S, Rubiano K, Klein MS, Baska KS, Krishna S, Klemba M, Roepe PD, Llinás M, Garcia CRS, Fidock DA. Lee AH, et al. Among authors: dhingra sk. Sci Rep. 2018 Sep 11;8(1):13578. doi: 10.1038/s41598-018-31715-9. Sci Rep. 2018. PMID: 30206341 Free PMC article.
Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265.
White J, Dhingra SK, Deng X, El Mazouni F, Lee MCS, Afanador GA, Lawong A, Tomchick DR, Ng CL, Bath J, Rathod PK, Fidock DA, Phillips MA. White J, et al. Among authors: dhingra sk. ACS Infect Dis. 2019 Jan 11;5(1):90-101. doi: 10.1021/acsinfecdis.8b00211. Epub 2018 Nov 13. ACS Infect Dis. 2019. PMID: 30375858 Free PMC article.
Plasmodium falciparum resistance to piperaquine driven by PfCRT.
Dhingra SK, Small-Saunders JL, Ménard D, Fidock DA. Dhingra SK, et al. Lancet Infect Dis. 2019 Nov;19(11):1168-1169. doi: 10.1016/S1473-3099(19)30543-2. Lancet Infect Dis. 2019. PMID: 31657776 Free PMC article. No abstract available.
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