Bracher F - Search Results

1

A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs.

Karlas A, Berre S, Couderc T, Varjak M, Braun P, Meyer M, Gangneux N, Karo-Astover L, Weege F, Raftery M, Schönrich G, Klemm U, Wurzlbauer A, Bracher F, Merits A, Meyer TF, Lecuit M. Karlas A, et al. Among authors: bracher f. Nat Commun. 2016 May 12;7:11320. doi: 10.1038/ncomms11320. Nat Commun. 2016. PMID: 27177310 Free PMC article.

2

Selectivity Profiling and Biological Activity of Novel β-Carbolines as Potent and Selective DYRK1 Kinase Inhibitors.

Rüben K, Wurzlbauer A, Walte A, Sippl W, Bracher F, Becker W. Rüben K, et al. Among authors: bracher f. PLoS One. 2015 Jul 20;10(7):e0132453. doi: 10.1371/journal.pone.0132453. eCollection 2015. PLoS One. 2015. PMID: 26192590 Free PMC article.

3

Regulation of influenza A virus mRNA splicing by CLK1.

Artarini A, Meyer M, Shin YJ, Huber K, Hilz N, Bracher F, Eros D, Orfi L, Keri G, Goedert S, Neuenschwander M, von Kries J, Domovich-Eisenberg Y, Dekel N, Szabadkai I, Lebendiker M, Horváth Z, Danieli T, Livnah O, Moncorgé O, Frise R, Barclay W, Meyer TF, Karlas A. Artarini A, et al. Among authors: bracher f. Antiviral Res. 2019 Aug;168:187-196. doi: 10.1016/j.antiviral.2019.06.003. Epub 2019 Jun 6. Antiviral Res. 2019. PMID: 31176694 Free article.

4

Expression, purification and crystallization of CLK1 kinase - A potential target for antiviral therapy.

Dekel N, Eisenberg-Domovich Y, Karlas A, Meyer TF, Bracher F, Lebendiker M, Danieli T, Livnah O. Dekel N, et al. Among authors: bracher f. Protein Expr Purif. 2020 Dec;176:105742. doi: 10.1016/j.pep.2020.105742. Epub 2020 Aug 29. Protein Expr Purif. 2020. PMID: 32866611

5

How to Separate Kinase Inhibition from Undesired Monoamine Oxidase A Inhibition-The Development of the DYRK1A Inhibitor AnnH75 from the Alkaloid Harmine.

Wurzlbauer A, Rüben K, Gürdal E, Chaikuad A, Knapp S, Sippl W, Becker W, Bracher F. Wurzlbauer A, et al. Among authors: bracher f. Molecules. 2020 Dec 16;25(24):5962. doi: 10.3390/molecules25245962. Molecules. 2020. PMID: 33339338 Free PMC article.

6

A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV.

Chen CC, Keller M, Hess M, Schiffmann R, Urban N, Wolfgardt A, Schaefer M, Bracher F, Biel M, Wahl-Schott C, Grimm C. Chen CC, et al. Among authors: bracher f. Nat Commun. 2014 Aug 14;5:4681. doi: 10.1038/ncomms5681. Nat Commun. 2014. PMID: 25119295 Free article.

7

High susceptibility to fatty liver disease in two-pore channel 2-deficient mice.

Grimm C, Holdt LM, Chen CC, Hassan S, Müller C, Jörs S, Cuny H, Kissing S, Schröder B, Butz E, Northoff B, Castonguay J, Luber CA, Moser M, Spahn S, Lüllmann-Rauch R, Fendel C, Klugbauer N, Griesbeck O, Haas A, Mann M, Bracher F, Teupser D, Saftig P, Biel M, Wahl-Schott C. Grimm C, et al. Among authors: bracher f. Nat Commun. 2014 Aug 21;5:4699. doi: 10.1038/ncomms5699. Nat Commun. 2014. PMID: 25144390 Free article.

8

Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination.

Hubler Z, Allimuthu D, Bederman I, Elitt MS, Madhavan M, Allan KC, Shick HE, Garrison E, T Karl M, Factor DC, Nevin ZS, Sax JL, Thompson MA, Fedorov Y, Jin J, Wilson WK, Giera M, Bracher F, Miller RH, Tesar PJ, Adams DJ. Hubler Z, et al. Among authors: bracher f. Nature. 2018 Aug;560(7718):372-376. doi: 10.1038/s41586-018-0360-3. Epub 2018 Jul 25. Nature. 2018. PMID: 30046109 Free PMC article.

9

Segregated cation flux by TPC2 biases Ca²⁺ signaling through lysosomes.

Yuan Y, Jaślan D, Rahman T, Bolsover SR, Arige V, Wagner LE 2nd, Abrahamian C, Tang R, Keller M, Hartmann J, Rosato AS, Weiden EM, Bracher F, Yule DI, Grimm C, Patel S. Yuan Y, et al. Among authors: bracher f. Nat Commun. 2022 Aug 2;13(1):4481. doi: 10.1038/s41467-022-31959-0. Nat Commun. 2022. PMID: 35918320 Free PMC article.

10

A gas chromatography-mass spectrometry-based whole-cell screening assay for target identification in distal cholesterol biosynthesis.

Müller C, Junker J, Bracher F, Giera M. Müller C, et al. Among authors: bracher f. Nat Protoc. 2019 Aug;14(8):2546-2570. doi: 10.1038/s41596-019-0193-z. Epub 2019 Jul 24. Nat Protoc. 2019. PMID: 31341291

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