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A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity.
Bramsen JB, Laursen MB, Nielsen AF, Hansen TB, Bus C, Langkjaer N, Babu BR, Højland T, Abramov M, Van Aerschot A, Odadzic D, Smicius R, Haas J, Andree C, Barman J, Wenska M, Srivastava P, Zhou C, Honcharenko D, Hess S, Müller E, Bobkov GV, Mikhailov SN, Fava E, Meyer TF, Chattopadhyaya J, Zerial M, Engels JW, Herdewijn P, Wengel J, Kjems J. Bramsen JB, et al. Among authors: hansen tb. Nucleic Acids Res. 2009 May;37(9):2867-81. doi: 10.1093/nar/gkp106. Epub 2009 Mar 12. Nucleic Acids Res. 2009. PMID: 19282453 Free PMC article.
A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects.
Bramsen JB, Pakula MM, Hansen TB, Bus C, Langkjær N, Odadzic D, Smicius R, Wengel SL, Chattopadhyaya J, Engels JW, Herdewijn P, Wengel J, Kjems J. Bramsen JB, et al. Among authors: hansen tb. Nucleic Acids Res. 2010 Sep;38(17):5761-73. doi: 10.1093/nar/gkq341. Epub 2010 May 7. Nucleic Acids Res. 2010. PMID: 20453030 Free PMC article.
The miR-143/-145 cluster regulates plasminogen activator inhibitor-1 in bladder cancer.
Villadsen SB, Bramsen JB, Ostenfeld MS, Wiklund ED, Fristrup N, Gao S, Hansen TB, Jensen TI, Borre M, Ørntoft TF, Dyrskjøt L, Kjems J. Villadsen SB, et al. Among authors: hansen tb. Br J Cancer. 2012 Jan 17;106(2):366-74. doi: 10.1038/bjc.2011.520. Epub 2011 Nov 22. Br J Cancer. 2012. PMID: 22108519 Free PMC article.
Natural RNA circles function as efficient microRNA sponges.
Hansen TB, Jensen TI, Clausen BH, Bramsen JB, Finsen B, Damgaard CK, Kjems J. Hansen TB, et al. Nature. 2013 Mar 21;495(7441):384-8. doi: 10.1038/nature11993. Epub 2013 Feb 27. Nature. 2013. PMID: 23446346
390 results