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Dehydroevodiamine and hortiamine, alkaloids from the traditional Chinese herbal drug Evodia rutaecarpa, are IKr blockers with proarrhythmic effects in vitro and in vivo.
Baburin I, Varkevisser R, Schramm A, Saxena P, Beyl S, Szkokan P, Linder T, Stary-Weinzinger A, van der Heyden MAG, Houtman M, Takanari H, Jonsson M, Beekman JHD, Hamburger M, Vos MA, Hering S. Baburin I, et al. Among authors: hering s. Pharmacol Res. 2018 May;131:150-163. doi: 10.1016/j.phrs.2018.02.024. Epub 2018 Mar 15. Pharmacol Res. 2018. PMID: 29477480 Free article.
Drug trapping in hERG K+ channels: (not) a matter of drug size?
Linder T, Bernsteiner H, Saxena P, Bauer F, Erker T, Timin E, Hering S, Stary-Weinzinger A. Linder T, et al. Among authors: hering s. Medchemcomm. 2016 Mar 1;7(3):512-518. doi: 10.1039/c5md00443h. Epub 2015 Dec 22. Medchemcomm. 2016. PMID: 28337337 Free PMC article.
337 results