Gavine PR - Search Results

1

Discovery of a novel allosteric inhibitor-binding site in ERK5: comparison with the canonical kinase hinge ATP-binding site.

Chen H, Tucker J, Wang X, Gavine PR, Phillips C, Augustin MA, Schreiner P, Steinbacher S, Preston M, Ogg D. Chen H, et al. Among authors: gavine pr. Acta Crystallogr D Struct Biol. 2016 May;72(Pt 5):682-93. doi: 10.1107/S2059798316004502. Epub 2016 Apr 26. Acta Crystallogr D Struct Biol. 2016. PMID: 27139631 Free PMC article.

2

Discovery of Highly Potent and Selective IRAK1 Degraders to Probe Scaffolding Functions of IRAK1 in ABC DLBCL.

Fu L, Zhang J, Shen B, Kong L, Liu Y, Tu W, Wang W, Cai X, Wang X, Cheng N, Xia M, Zhou T, Liu Q, Xu Y, Yang J, Gavine P, Philippar U, Attar R, Edwards JP, Venable JD, Dai X. Fu L, et al. J Med Chem. 2021 Aug 12;64(15):10878-10889. doi: 10.1021/acs.jmedchem.1c00103. Epub 2021 Jul 19. J Med Chem. 2021. PMID: 34279092

3

Assessing IRAK4 Functions in ABC DLBCL by IRAK4 Kinase Inhibition and Protein Degradation.

Zhang J, Fu L, Shen B, Liu Y, Wang W, Cai X, Kong L, Yan Y, Meng R, Zhang Z, Chen YP, Liu Q, Wan ZK, Zhou T, Wang X, Gavine P, Del Rosario A, Ahn K, Philippar U, Attar R, Yang J, Xu Y, Edwards JP, Dai X. Zhang J, et al. Cell Chem Biol. 2020 Dec 17;27(12):1500-1509.e13. doi: 10.1016/j.chembiol.2020.08.010. Epub 2020 Sep 3. Cell Chem Biol. 2020. PMID: 32888499 Free article.

4

Identification and validation of dysregulated MAPK7 (ERK5) as a novel oncogenic target in squamous cell lung and esophageal carcinoma.

Gavine PR, Wang M, Yu D, Hu E, Huang C, Xia J, Su X, Fan J, Zhang T, Ye Q, Zheng L, Zhu G, Qian Z, Luo Q, Hou YY, Ji Q. Gavine PR, et al. BMC Cancer. 2015 Jun 4;15:454. doi: 10.1186/s12885-015-1455-y. BMC Cancer. 2015. PMID: 26040563 Free PMC article.

5

AZD4547: an orally bioavailable, potent, and selective inhibitor of the fibroblast growth factor receptor tyrosine kinase family.

Gavine PR, Mooney L, Kilgour E, Thomas AP, Al-Kadhimi K, Beck S, Rooney C, Coleman T, Baker D, Mellor MJ, Brooks AN, Klinowska T. Gavine PR, et al. Cancer Res. 2012 Apr 15;72(8):2045-56. doi: 10.1158/0008-5472.CAN-11-3034. Epub 2012 Feb 27. Cancer Res. 2012. PMID: 22369928

6

FGFR2 gene amplification in gastric cancer predicts sensitivity to the selective FGFR inhibitor AZD4547.

Xie L, Su X, Zhang L, Yin X, Tang L, Zhang X, Xu Y, Gao Z, Liu K, Zhou M, Gao B, Shen D, Zhang L, Ji J, Gavine PR, Zhang J, Kilgour E, Zhang X, Ji Q. Xie L, et al. Among authors: gavine pr. Clin Cancer Res. 2013 May 1;19(9):2572-83. doi: 10.1158/1078-0432.CCR-12-3898. Epub 2013 Mar 14. Clin Cancer Res. 2013. PMID: 23493349

7

Translating the therapeutic potential of AZD4547 in FGFR1-amplified non-small cell lung cancer through the use of patient-derived tumor xenograft models.

Zhang J, Zhang L, Su X, Li M, Xie L, Malchers F, Fan S, Yin X, Xu Y, Liu K, Dong Z, Zhu G, Qian Z, Tang L, Schöttle J, Zhan P, Ji Q, Kilgour E, Smith PD, Brooks AN, Thomas RK, Gavine PR. Zhang J, et al. Among authors: gavine pr. Clin Cancer Res. 2012 Dec 15;18(24):6658-67. doi: 10.1158/1078-0432.CCR-12-2694. Epub 2012 Oct 18. Clin Cancer Res. 2012. PMID: 23082000

8

An evaluation and recommendation of the optimal methodologies to detect RET gene rearrangements in papillary thyroid carcinoma.

Zhang T, Lu Y, Ye Q, Zhang M, Zheng L, Yin X, Gavine P, Sun Z, Ji Q, Zhu G, Su X. Zhang T, et al. Genes Chromosomes Cancer. 2015 Mar;54(3):168-76. doi: 10.1002/gcc.22229. Epub 2014 Nov 19. Genes Chromosomes Cancer. 2015. PMID: 25407564

9

Trastuzumab anti-tumor efficacy in patient-derived esophageal squamous cell carcinoma xenograft (PDECX) mouse models.

Wu X, Zhang J, Zhen R, Lv J, Zheng L, Su X, Zhu G, Gavine PR, Xu S, Lu S, Hou J, Liu Y, Xu C, Tan Y, Xie L, Yin X, He D, Ji Q, Hou Y, Ge D. Wu X, et al. Among authors: gavine pr. J Transl Med. 2012 Aug 30;10:180. doi: 10.1186/1479-5876-10-180. J Transl Med. 2012. PMID: 22935382 Free PMC article.

10

Evaluation of Trastuzumab Anti-Tumor Efficacy and its Correlation with HER-2 Status in Patient-Derived Gastric Adenocarcinoma Xenograft Models.

Chen H, Ye Q, Lv J, Ye P, Sun Y, Fan S, Su X, Gavine P, Yin X. Chen H, et al. Pathol Oncol Res. 2015 Sep;21(4):947-55. doi: 10.1007/s12253-015-9909-8. Epub 2015 Mar 9. Pathol Oncol Res. 2015. PMID: 25749810 Free PMC article.

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