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Sideromimic Modification of Lactivicin Dramatically Increases Potency against Extensively Drug-Resistant Stenotrophomonas maltophilia Clinical Isolates.
Calvopiña K, Umland KD, Rydzik AM, Hinchliffe P, Brem J, Spencer J, Schofield CJ, Avison MB. Calvopiña K, et al. Among authors: spencer j. Antimicrob Agents Chemother. 2016 Jun 20;60(7):4170-5. doi: 10.1128/AAC.00371-16. Print 2016 Jul. Antimicrob Agents Chemother. 2016. PMID: 27139464 Free PMC article.
blaNDM-1 is a chimera likely constructed in Acinetobacter baumannii.
Toleman MA, Spencer J, Jones L, Walsh TR. Toleman MA, et al. Among authors: spencer j. Antimicrob Agents Chemother. 2012 May;56(5):2773-6. doi: 10.1128/AAC.06297-11. Epub 2012 Feb 6. Antimicrob Agents Chemother. 2012. PMID: 22314529 Free PMC article.
Assay platform for clinically relevant metallo-β-lactamases.
van Berkel SS, Brem J, Rydzik AM, Salimraj R, Cain R, Verma A, Owens RJ, Fishwick CW, Spencer J, Schofield CJ. van Berkel SS, et al. Among authors: spencer j. J Med Chem. 2013 Sep 12;56(17):6945-53. doi: 10.1021/jm400769b. Epub 2013 Aug 16. J Med Chem. 2013. PMID: 23898798 Free PMC article.
Studying the active-site loop movement of the São Paolo metallo-β-lactamase-1†Electronic supplementary information (ESI) available: Procedures for protein expression and purification, 19F-labelling, crystallisation, data collection, and structure determination, table of crystallographic data, table of crystallographic parameters and refinement statistics, figures showing binding mode and distances, procedures for mass spectrometry measurements, differential scanning fluorimetry measurements, stopped-flow measurements and other kinetics measurements. See DOI: 10.1039/c4sc01752hClick here for additional data file.
Brem J, Struwe WB, Rydzik AM, Tarhonskaya H, Pfeffer I, Flashman E, van Berkel SS, Spencer J, Claridge TD, McDonough MA, Benesch JL, Schofield CJ. Brem J, et al. Among authors: spencer j. Chem Sci. 2015 Feb 19;6(2):956-963. doi: 10.1039/c4sc01752h. Epub 2014 Nov 4. Chem Sci. 2015. PMID: 25717359 Free PMC article.
3,114 results