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In β-actin knockouts, epigenetic reprogramming and rDNA transcription inactivation lead to growth and proliferation defects.
Almuzzaini B, Sarshad AA, Rahmanto AS, Hansson ML, Von Euler A, Sangfelt O, Visa N, Farrants AK, Percipalle P. Almuzzaini B, et al. FASEB J. 2016 Aug;30(8):2860-73. doi: 10.1096/fj.201600280R. Epub 2016 Apr 28. FASEB J. 2016. PMID: 27127100
Within the rDNA, the distribution of beta-actin correlated with NM1 and the other subunits of the B-WICH complex, WSTF and SNF2h. In beta-actin(-/-) mouse embryonic fibroblasts (MEFs), we found that rRNA synthesis levels decreased concomitantly with drops in RNA polymerase …
Within the rDNA, the distribution of beta-actin correlated with NM1 and the other subunits of the B-WICH complex, WSTF and SNF2h. In …
β-Actin-dependent global chromatin organization and gene expression programs control cellular identity.
Xie X, Almuzzaini B, Drou N, Kremb S, Yousif A, Farrants AÖ, Gunsalus K, Percipalle P. Xie X, et al. Among authors: almuzzaini b. FASEB J. 2018 Mar;32(3):1296-1314. doi: 10.1096/fj.201700753R. Epub 2018 Jan 3. FASEB J. 2018. PMID: 29101221
Our results suggest that, by affecting the genome-wide organization of heterochromatin through the chromatin-binding activity of the BAF complex, beta-actin plays an essential role in the determination of gene expression programs and cellular identity.-Xie, X., Almuzzaini, …
Our results suggest that, by affecting the genome-wide organization of heterochromatin through the chromatin-binding activity of the BAF com …
Pancytopenia, Recurrent Infection, Poor Wound Healing, Heterotopia of the Brain Probably Associated with A Candidate Novel de Novo CDC42 Gene Defect: Expanding the Molecular and Phenotypic Spectrum.
Asiri A, Alwadaani D, Umair M, Alhamoudi KM, Almuhanna MH, Nasir A, Alrfaei BM, Al Tuwaijri A, Barhoumi T, Alyafee Y, Almuzzaini B, Aldrees M, Ballow M, Alayyar L, Al Abdulrahman A, Alhaidan Y, Al Ghasham N, Al-Ajaji S, Alsalamah M, Al Suwairi W, Alfadhel M. Asiri A, et al. Among authors: almuzzaini b. Genes (Basel). 2021 Feb 20;12(2):294. doi: 10.3390/genes12020294. Genes (Basel). 2021. PMID: 33672558 Free PMC article.
29 results