Parmar R - Search Results

1

5'-(E)-Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA-GalNAc Conjugates.

Parmar R, Willoughby JL, Liu J, Foster DJ, Brigham B, Theile CS, Charisse K, Akinc A, Guidry E, Pei Y, Strapps W, Cancilla M, Stanton MG, Rajeev KG, Sepp-Lorenzino L, Manoharan M, Meyers R, Maier MA, Jadhav V. Parmar R, et al. Chembiochem. 2016 Jun 2;17(11):985-9. doi: 10.1002/cbic.201600130. Epub 2016 Apr 28. Chembiochem. 2016. PMID: 27121751

2

Facile Synthesis, Geometry, and 2'-Substituent-Dependent in Vivo Activity of 5'-(E)- and 5'-(Z)-Vinylphosphonate-Modified siRNA Conjugates.

Parmar RG, Brown CR, Matsuda S, Willoughby JLS, Theile CS, Charissé K, Foster DJ, Zlatev I, Jadhav V, Maier MA, Egli M, Manoharan M, Rajeev KG. Parmar RG, et al. J Med Chem. 2018 Feb 8;61(3):734-744. doi: 10.1021/acs.jmedchem.7b01147. Epub 2018 Jan 27. J Med Chem. 2018. PMID: 29376650

3

siRNA carrying an (E)-vinylphosphonate moiety at the 5΄ end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2.

Elkayam E, Parmar R, Brown CR, Willoughby JL, Theile CS, Manoharan M, Joshua-Tor L. Elkayam E, et al. Among authors: parmar r. Nucleic Acids Res. 2017 Apr 7;45(6):3528-3536. doi: 10.1093/nar/gkw1171. Nucleic Acids Res. 2017. PMID: 27903888 Free PMC article.

4

Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity.

Janas MM, Schlegel MK, Harbison CE, Yilmaz VO, Jiang Y, Parmar R, Zlatev I, Castoreno A, Xu H, Shulga-Morskaya S, Rajeev KG, Manoharan M, Keirstead ND, Maier MA, Jadhav V. Janas MM, et al. Among authors: parmar r. Nat Commun. 2018 Feb 19;9(1):723. doi: 10.1038/s41467-018-02989-4. Nat Commun. 2018. PMID: 29459660 Free PMC article.

5

5'-C-Malonyl RNA: Small Interfering RNAs Modified with 5'-Monophosphate Bioisostere Demonstrate Gene Silencing Activity.

Zlatev I, Foster DJ, Liu J, Charisse K, Brigham B, Parmar RG, Jadhav V, Maier MA, Rajeev KG, Egli M, Manoharan M. Zlatev I, et al. ACS Chem Biol. 2016 Apr 15;11(4):953-60. doi: 10.1021/acschembio.5b00654. Epub 2016 Jan 13. ACS Chem Biol. 2016. PMID: 26675211

6

5'-Morpholino modification of the sense strand of an siRNA makes it a more effective passenger.

Kumar P , Parmar RG , Brown CR , Willoughby JLS , Foster DJ , Babu IR , Schofield S , Jadhav V , Charisse K , Nair JK , Rajeev KG , Maier MA , Egli M , Manoharan M . Kumar P , et al. Among authors: parmar rg. Chem Commun (Camb). 2019 Apr 25;55(35):5139-5142. doi: 10.1039/c9cc00977a. Chem Commun (Camb). 2019. PMID: 30977478

7

Investigating the pharmacodynamic durability of GalNAc-siRNA conjugates.

Brown CR, Gupta S, Qin J, Racie T, He G, Lentini S, Malone R, Yu M, Matsuda S, Shulga-Morskaya S, Nair AV, Theile CS, Schmidt K, Shahraz A, Goel V, Parmar RG, Zlatev I, Schlegel MK, Nair JK, Jayaraman M, Manoharan M, Brown D, Maier MA, Jadhav V. Brown CR, et al. Among authors: parmar rg. Nucleic Acids Res. 2020 Dec 2;48(21):11827-11844. doi: 10.1093/nar/gkaa670. Nucleic Acids Res. 2020. PMID: 32808038 Free PMC article.

8

siRNA carrying an (E)-vinylphosphonate moiety at the 5΄ end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2.

Elkayam E, Parmar R, Brown CR, Willoughby JL, Theile CS, Manoharan M, Joshua-Tor L. Elkayam E, et al. Among authors: parmar r. Nucleic Acids Res. 2017 May 5;45(8):5008. doi: 10.1093/nar/gkw1298. Nucleic Acids Res. 2017. PMID: 27986853 Free PMC article. No abstract available.

9

Centyrin ligands for extrahepatic delivery of siRNA.

Klein D, Goldberg S, Theile CS, Dambra R, Haskell K, Kuhar E, Lin T, Parmar R, Manoharan M, Richter M, Wu M, Mendrola Zarazowski J, Jadhav V, Maier MA, Sepp-Lorenzino L, O'Neil K, Dudkin V. Klein D, et al. Among authors: parmar r. Mol Ther. 2021 Jun 2;29(6):2053-2066. doi: 10.1016/j.ymthe.2021.02.015. Epub 2021 Feb 15. Mol Ther. 2021. PMID: 33601052 Free PMC article.

10

Improving the in vivo therapeutic index of siRNA polymer conjugates through increasing pH responsiveness.

Guidry EN, Farand J, Soheili A, Parish CA, Kevin NJ, Pipik B, Calati KB, Ikemoto N, Waldman JH, Latham AH, Howell BJ, Leone A, Garbaccio RM, Barrett SE, Parmar RG, Truong QT, Mao B, Davies IW, Colletti SL, Sepp-Lorenzino L. Guidry EN, et al. Bioconjug Chem. 2014 Feb 19;25(2):296-307. doi: 10.1021/bc400442p. Epub 2014 Jan 10. Bioconjug Chem. 2014. PMID: 24409989

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