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Discovery of novel thiosemicarbazone-acridine targeting butyrylcholinesterase with antioxidant, metal complexing and neuroprotector abilities as potential treatment of Alzheimer's disease: In vitro, in vivo, and in silico studies.
Silva Sousa GL, Nadur NF, de Almeida Peixoto Ferreira L, da Silva Honório T, Simon A, Cabral LM, Móra Santos ML, Andrade B, de Lima EV, Clarke JR, Castro RN, Olímpio de Moura R, Kümmerle AE. Silva Sousa GL, et al. Among authors: de lima ev. Eur J Med Chem. 2025 Jan 5;281:117030. doi: 10.1016/j.ejmech.2024.117030. Epub 2024 Nov 7. Eur J Med Chem. 2025. PMID: 39531933
Abatacept inhibits Th17 differentiation and mitigates α-synuclein-induced dopaminergic dysfunction in mice.
Clarke JR, Bacelar TS, Fernandes GG, Silva RCD, Antonio LS, Queiroz M, de Souza RV, Valadão LF, Ribeiro GS, De Lima EV, Colodeti LC, Mangeth LC, Wiecikowski A, da Silva TN, Paula-Neto HA, da Costa R, Cordeiro Y, Passos GF, Figueiredo CP. Clarke JR, et al. Among authors: de lima ev. Mol Psychiatry. 2025 Feb;30(2):547-555. doi: 10.1038/s41380-024-02618-1. Epub 2024 Aug 16. Mol Psychiatry. 2025. PMID: 39152331
Immunosuppression-induced Zika virus reactivation causes brain inflammation and behavioral deficits in mice.
Nogueira CO, Lopes da Silva MO, de Lima EV, Christoff RR, Gavino-Leopoldino D, Lemos FS, da Silva NE, Da Poian AT, Assunção-Miranda I, Figueiredo CP, Clarke JR. Nogueira CO, et al. Among authors: de lima ev. iScience. 2024 Jun 5;27(7):110178. doi: 10.1016/j.isci.2024.110178. eCollection 2024 Jul 19. iScience. 2024. PMID: 38993676 Free PMC article.
SARS-CoV-2 Spike protein alters microglial purinergic signaling.
Alves VS, Santos SACS, Leite-Aguiar R, Paiva-Pereira E, Dos Reis RR, Calazans ML, Fernandes GG, Antônio LS, de Lima EV, Kurtenbach E, Silva JL, Fontes-Dantas FL, Passos GF, Figueiredo CP, Coutinho-Silva R, Savio LEB. Alves VS, et al. Among authors: de lima ev. Front Immunol. 2023 Apr 11;14:1158460. doi: 10.3389/fimmu.2023.1158460. eCollection 2023. Front Immunol. 2023. PMID: 37114062 Free PMC article.
SARS-CoV-2 Spike protein induces TLR4-mediated long-term cognitive dysfunction recapitulating post-COVID-19 syndrome in mice.
Fontes-Dantas FL, Fernandes GG, Gutman EG, De Lima EV, Antonio LS, Hammerle MB, Mota-Araujo HP, Colodeti LC, Araújo SMB, Froz GM, da Silva TN, Duarte LA, Salvio AL, Pires KL, Leon LAA, Vasconcelos CCF, Romão L, Savio LEB, Silva JL, da Costa R, Clarke JR, Da Poian AT, Alves-Leon SV, Passos GF, Figueiredo CP. Fontes-Dantas FL, et al. Among authors: de lima ev. Cell Rep. 2023 Mar 28;42(3):112189. doi: 10.1016/j.celrep.2023.112189. Epub 2023 Feb 17. Cell Rep. 2023. PMID: 36857178 Free PMC article.
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