Keune WJ - Search Results

1

Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling.

Keune WJ, Hausmann J, Bolier R, Tolenaars D, Kremer A, Heidebrecht T, Joosten RP, Sunkara M, Morris AJ, Matas-Rico E, Moolenaar WH, Oude Elferink RP, Perrakis A. Keune WJ, et al. Nat Commun. 2016 Apr 14;7:11248. doi: 10.1038/ncomms11248. Nat Commun. 2016. PMID: 27075612 Free PMC article.

2

Structural snapshots of the catalytic cycle of the phosphodiesterase Autotaxin.

Hausmann J, Keune WJ, Hipgrave Ederveen AL, van Zeijl L, Joosten RP, Perrakis A. Hausmann J, et al. Among authors: keune wj. J Struct Biol. 2016 Aug;195(2):199-206. doi: 10.1016/j.jsb.2016.06.002. Epub 2016 Jun 4. J Struct Biol. 2016. PMID: 27268273

3

Lysophosphatidic acid produced by autotaxin acts as an allosteric modulator of its catalytic efficiency.

Salgado-Polo F, Fish A, Matsoukas MT, Heidebrecht T, Keune WJ, Perrakis A. Salgado-Polo F, et al. Among authors: keune wj. J Biol Chem. 2018 Sep 14;293(37):14312-14327. doi: 10.1074/jbc.RA118.004450. Epub 2018 Jul 19. J Biol Chem. 2018. PMID: 30026231 Free PMC article.

4

Rational Design of Autotaxin Inhibitors by Structural Evolution of Endogenous Modulators.

Keune WJ, Potjewyd F, Heidebrecht T, Salgado-Polo F, Macdonald SJ, Chelvarajan L, Abdel Latif A, Soman S, Morris AJ, Watson AJ, Jamieson C, Perrakis A. Keune WJ, et al. J Med Chem. 2017 Mar 9;60(5):2006-2017. doi: 10.1021/acs.jmedchem.6b01743. Epub 2017 Feb 16. J Med Chem. 2017. PMID: 28165241 Free article.

5

Structure-Activity Relationships of Small Molecule Autotaxin Inhibitors with a Discrete Binding Mode.

Miller LM, Keune WJ, Castagna D, Young LC, Duffy EL, Potjewyd F, Salgado-Polo F, Engel García P, Semaan D, Pritchard JM, Perrakis A, Macdonald SJ, Jamieson C, Watson AJ. Miller LM, et al. Among authors: keune wj. J Med Chem. 2017 Jan 26;60(2):722-748. doi: 10.1021/acs.jmedchem.6b01597. Epub 2017 Jan 5. J Med Chem. 2017. PMID: 27982588 Free article.

6

Rac controls PIP5K localisation and PtdIns(4,5)P₂ synthesis, which modulates vinculin localisation and neurite dynamics.

Halstead JR, Savaskan NE, van den Bout I, Van Horck F, Hajdo-Milasinovic A, Snell M, Keune WJ, Ten Klooster JP, Hordijk PL, Divecha N. Halstead JR, et al. Among authors: keune wj. J Cell Sci. 2010 Oct 15;123(Pt 20):3535-46. doi: 10.1242/jcs.062679. Epub 2010 Sep 14. J Cell Sci. 2010. PMID: 20841379

7

Methods for the determination of the mass of nuclear PtdIns4P, PtdIns5P, and PtdIns(4,5)P2.

Jones DR, Bultsma Y, Keune WJ, Divecha N. Jones DR, et al. Among authors: keune wj. Methods Mol Biol. 2009;462:75-88. doi: 10.1007/978-1-60327-115-8_5. Methods Mol Biol. 2009. PMID: 19160662

8

Nuclear PtdIns5P as a transducer of stress signaling: an in vivo role for PIP4Kbeta.

Jones DR, Bultsma Y, Keune WJ, Halstead JR, Elouarrat D, Mohammed S, Heck AJ, D'Santos CS, Divecha N. Jones DR, et al. Among authors: keune wj. Mol Cell. 2006 Sep 1;23(5):685-95. doi: 10.1016/j.molcel.2006.07.014. Mol Cell. 2006. PMID: 16949365 Free article.

9

Collaboration of AMPK and PKC to induce phosphorylation of Ser413 on PIP5K1B resulting in decreased kinase activity and reduced PtdIns(4,5)P2 synthesis in response to oxidative stress and energy restriction.

van den Bout I, Jones DR, Shah ZH, Halstead JR, Keune WJ, Mohammed S, D'Santos CS, Divecha N. van den Bout I, et al. Among authors: keune wj. Biochem J. 2013 Nov 1;455(3):347-58. doi: 10.1042/BJ20130259. Biochem J. 2013. PMID: 23909401

10

PIP4Kbeta interacts with and modulates nuclear localization of the high-activity PtdIns5P-4-kinase isoform PIP4Kalpha.

Bultsma Y, Keune WJ, Divecha N. Bultsma Y, et al. Among authors: keune wj. Biochem J. 2010 Sep 1;430(2):223-35. doi: 10.1042/BJ20100341. Biochem J. 2010. PMID: 20583997

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