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Deciphering intra-tumor heterogeneity of lung adenocarcinoma confirms that dominant, branching, and private gene mutations occur within individual tumor nodules.
Pelosi G, Pellegrinelli A, Fabbri A, Tamborini E, Perrone F, Settanni G, Busico A, Picciani B, Testi MA, Militti L, Maisonneuve P, Valeri B, Sonzogni A, Proto C, Garassino M, De Braud F, Pastorino U. Pelosi G, et al. Virchows Arch. 2016 Jun;468(6):651-62. doi: 10.1007/s00428-016-1931-z. Epub 2016 Apr 7. Virchows Arch. 2016. PMID: 27056568
A subset of high-grade pulmonary neuroendocrine carcinomas shows up-regulation of matrix metalloproteinase-7 associated with nuclear beta-catenin immunoreactivity, independent of EGFR and HER-2 gene amplification or expression.
Pelosi G, Scarpa A, Veronesi G, Spaggiari L, Del Curto B, Moore PS, Maisonneuve P, Sonzogni A, Masullo M, Viale G. Pelosi G, et al. Virchows Arch. 2005 Dec;447(6):969-77. doi: 10.1007/s00428-005-0044-x. Epub 2005 Sep 13. Virchows Arch. 2005. PMID: 16158183
Does immunohistochemistry affect response to therapy and survival of inoperable non-small cell lung carcinoma patients? A survey of 145 stage III-IV consecutive cases.
Pelosi G, Haspinger ER, Bimbatti M, Leone G, Paolini B, Fabbri A, Tamborini E, Perrone F, Testi A, Garassino M, Maisonneuve P, de Braud F, Pilotti S, Pastorino U. Pelosi G, et al. Int J Surg Pathol. 2014 Apr;22(2):136-48. doi: 10.1177/1066896913511527. Epub 2013 Dec 9. Int J Surg Pathol. 2014. PMID: 24326823
Ki-67 labeling index of neuroendocrine tumors of the lung has a high level of correspondence between biopsy samples and surgical specimens when strict counting guidelines are applied.
Fabbri A, Cossa M, Sonzogni A, Papotti M, Righi L, Gatti G, Maisonneuve P, Valeri B, Pastorino U, Pelosi G. Fabbri A, et al. Among authors: pelosi g. Virchows Arch. 2017 Feb;470(2):153-164. doi: 10.1007/s00428-016-2062-2. Epub 2017 Jan 4. Virchows Arch. 2017. PMID: 28054150 Free article.
Thymus neuroendocrine tumors with CTNNB1 gene mutations, disarrayed ß-catenin expression, and dual intra-tumor Ki-67 labeling index compartmentalization challenge the concept of secondary high-grade neuroendocrine tumor: a paradigm shift.
Fabbri A, Cossa M, Sonzogni A, Bidoli P, Canova S, Cortinovis D, Abbate MI, Calabrese F, Nannini N, Lunardi F, Rossi G, La Rosa S, Capella C, Tamborini E, Perrone F, Busico A, Capone I, Valeri B, Pastorino U, Albini A, Pelosi G. Fabbri A, et al. Among authors: pelosi g. Virchows Arch. 2017 Jul;471(1):31-47. doi: 10.1007/s00428-017-2130-2. Epub 2017 Apr 27. Virchows Arch. 2017. PMID: 28451756
701 results