Pitt WR - Search Results

1

Identifying Interactions that Determine Fragment Binding at Protein Hotspots.

Radoux CJ, Olsson TS, Pitt WR, Groom CR, Blundell TL. Radoux CJ, et al. Among authors: pitt wr. J Med Chem. 2016 May 12;59(9):4314-25. doi: 10.1021/acs.jmedchem.5b01980. Epub 2016 Apr 11. J Med Chem. 2016. PMID: 27043011

2

IRAK-4 inhibitors. Part II: a structure-based assessment of imidazo[1,2-a]pyridine binding.

Buckley GM, Ceska TA, Fraser JL, Gowers L, Groom CR, Higueruelo AP, Jenkins K, Mack SR, Morgan T, Parry DM, Pitt WR, Rausch O, Richard MD, Sabin V. Buckley GM, et al. Among authors: pitt wr. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3291-5. doi: 10.1016/j.bmcl.2008.04.039. Epub 2008 Apr 22. Bioorg Med Chem Lett. 2008. PMID: 18482836

3

The thermodynamics of protein-ligand interaction and solvation: insights for ligand design.

Olsson TS, Williams MA, Pitt WR, Ladbury JE. Olsson TS, et al. Among authors: pitt wr. J Mol Biol. 2008 Dec 26;384(4):1002-17. doi: 10.1016/j.jmb.2008.09.073. Epub 2008 Oct 9. J Mol Biol. 2008. PMID: 18930735

4

Heteroaromatic rings of the future.

Pitt WR, Parry DM, Perry BG, Groom CR. Pitt WR, et al. J Med Chem. 2009 May 14;52(9):2952-63. doi: 10.1021/jm801513z. J Med Chem. 2009. PMID: 19348472

5

On the origins of enzyme inhibitor selectivity and promiscuity: a case study of protein kinase binding to staurosporine.

Tanramluk D, Schreyer A, Pitt WR, Blundell TL. Tanramluk D, et al. Among authors: pitt wr. Chem Biol Drug Des. 2009 Jul;74(1):16-24. doi: 10.1111/j.1747-0285.2009.00832.x. Chem Biol Drug Des. 2009. PMID: 19519740 Free PMC article.

6

Structural interactomics: informatics approaches to aid the interpretation of genetic variation and the development of novel therapeutics.

Lee S, Brown A, Pitt WR, Higueruelo AP, Gong S, Bickerton GR, Schreyer A, Tanramluk D, Baylay A, Blundell TL. Lee S, et al. Among authors: pitt wr. Mol Biosyst. 2009 Dec;5(12):1456-72. doi: 10.1039/B906402h. Epub 2009 Aug 6. Mol Biosyst. 2009. PMID: 19763326 Review.

7

Atomic interactions and profile of small molecules disrupting protein-protein interfaces: the TIMBAL database.

Higueruelo AP, Schreyer A, Bickerton GR, Pitt WR, Groom CR, Blundell TL. Higueruelo AP, et al. Among authors: pitt wr. Chem Biol Drug Des. 2009 Nov;74(5):457-67. doi: 10.1111/j.1747-0285.2009.00889.x. Chem Biol Drug Des. 2009. PMID: 19811506

8

Extent of enthalpy-entropy compensation in protein-ligand interactions.

Olsson TS, Ladbury JE, Pitt WR, Williams MA. Olsson TS, et al. Among authors: pitt wr. Protein Sci. 2011 Sep;20(9):1607-18. doi: 10.1002/pro.692. Epub 2011 Aug 2. Protein Sci. 2011. PMID: 21739503 Free PMC article.

9

Biophysical and computational fragment-based approaches to targeting protein-protein interactions: applications in structure-guided drug discovery.

Winter A, Higueruelo AP, Marsh M, Sigurdardottir A, Pitt WR, Blundell TL. Winter A, et al. Among authors: pitt wr. Q Rev Biophys. 2012 Nov;45(4):383-426. doi: 10.1017/S0033583512000108. Epub 2012 Sep 13. Q Rev Biophys. 2012. PMID: 22971516 Review.

10

What can we learn from the evolution of protein-ligand interactions to aid the design of new therapeutics?

Higueruelo AP, Schreyer A, Bickerton GR, Blundell TL, Pitt WR. Higueruelo AP, et al. Among authors: pitt wr. PLoS One. 2012;7(12):e51742. doi: 10.1371/journal.pone.0051742. Epub 2012 Dec 11. PLoS One. 2012. PMID: 23240060 Free PMC article.

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