El-Mezgueldi M - Search Results

1

Mutations in troponin T associated with Hypertrophic Cardiomyopathy increase Ca(2+)-sensitivity and suppress the modulation of Ca(2+)-sensitivity by troponin I phosphorylation.

Messer AE, Bayliss CR, El-Mezgueldi M, Redwood CS, Ward DG, Leung MC, Papadaki M, Dos Remedios C, Marston SB. Messer AE, et al. Among authors: el mezgueldi m. Arch Biochem Biophys. 2016 Jul 1;601:113-20. doi: 10.1016/j.abb.2016.03.027. Epub 2016 Mar 29. Arch Biochem Biophys. 2016. PMID: 27036851 Free PMC article.

2

The effect of mutations in alpha-tropomyosin (E40K and E54K) that cause familial dilated cardiomyopathy on the regulatory mechanism of cardiac muscle thin filaments.

Mirza M, Robinson P, Kremneva E, Copeland O, Nikolaeva O, Watkins H, Levitsky D, Redwood C, El-Mezgueldi M, Marston S. Mirza M, et al. J Biol Chem. 2007 May 4;282(18):13487-97. doi: 10.1074/jbc.M701071200. Epub 2007 Mar 13. J Biol Chem. 2007. PMID: 17360712 Free article.

3

Mutations in repeating structural motifs of tropomyosin cause gain of function in skeletal muscle myopathy patients.

Marston S, Memo M, Messer A, Papadaki M, Nowak K, McNamara E, Ong R, El-Mezgueldi M, Li X, Lehman W. Marston S, et al. Among authors: el mezgueldi m. Hum Mol Genet. 2013 Dec 15;22(24):4978-87. doi: 10.1093/hmg/ddt345. Epub 2013 Jul 25. Hum Mol Genet. 2013. PMID: 23886664 Free PMC article.

4

Role of caldesmon in the Ca2+ regulation of smooth muscle thin filaments: evidence for a cooperative switching mechanism.

Ansari S, Alahyan M, Marston SB, El-Mezgueldi M. Ansari S, et al. J Biol Chem. 2008 Jan 4;283(1):47-56. doi: 10.1074/jbc.M706771200. Epub 2007 Oct 12. J Biol Chem. 2008. PMID: 17933868 Free article.

5

Cooperative inhibition of actin filaments in the absence of tropomyosin.

Ansari S, El-Mezgueldi M, Marston S. Ansari S, et al. J Muscle Res Cell Motil. 2003;24(8):513-20. doi: 10.1023/b:jure.0000009812.74980.13. J Muscle Res Cell Motil. 2003. PMID: 14870966

6

Structure-activity studies of the regulatory interaction of the 10 kilodalton C-terminal fragment of caldesmon with actin and the effect of mutation of caldesmon residues 691-696.

Huber PA, Gao Y, Fraser ID, Copeland O, EL-Mezgueldi M, Slatter DA, Keane NE, Marston SB, Levine BA. Huber PA, et al. Biochemistry. 1998 Feb 24;37(8):2314-26. doi: 10.1021/bi971727b. Biochemistry. 1998. PMID: 9485378

7

Structural interactions between actin, tropomyosin, caldesmon and calcium binding protein and the regulation of smooth muscle thin filaments.

Marston S, Burton D, Copeland O, Fraser I, Gao Y, Hodgkinson J, Huber P, Levine B, el-Mezgueldi M, Notarianni G. Marston S, et al. Acta Physiol Scand. 1998 Dec;164(4):401-14. doi: 10.1111/j.1365-201x.1998.tb10696.x. Acta Physiol Scand. 1998. PMID: 9887964 Review.

8

Multiple-sited interaction of caldesmon with Ca(2+)-calmodulin.

Huber PA, El-Mezgueldi M, Grabarek Z, Slatter DA, Levine BA, Marston SB. Huber PA, et al. Biochem J. 1996 Jun 1;316 ( Pt 2)(Pt 2):413-20. doi: 10.1042/bj3160413. Biochem J. 1996. PMID: 8687382 Free PMC article.

9

The effects of smooth muscle calponin on the strong and weak myosin binding sites of F-actin.

EL-Mezgueldi M, Marston SB. EL-Mezgueldi M, et al. J Biol Chem. 1996 Nov 8;271(45):28161-7. doi: 10.1074/jbc.271.45.28161. J Biol Chem. 1996. PMID: 8910431 Free article.

10

The mechanism of smooth muscle caldesmon-tropomyosin inhibition of the elementary steps of the actomyosin ATPase.

Alahyan M, Webb MR, Marston SB, El-Mezgueldi M. Alahyan M, et al. J Biol Chem. 2006 Jul 14;281(28):19433-48. doi: 10.1074/jbc.M507602200. Epub 2006 Mar 15. J Biol Chem. 2006. PMID: 16540476 Free article.

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