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Functional identification of a neurocircuit regulating blood glucose.
Meek TH, Nelson JT, Matsen ME, Dorfman MD, Guyenet SJ, Damian V, Allison MB, Scarlett JM, Nguyen HT, Thaler JP, Olson DP, Myers MG Jr, Schwartz MW, Morton GJ. Meek TH, et al. Among authors: guyenet sj. Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):E2073-82. doi: 10.1073/pnas.1521160113. Epub 2016 Mar 21. Proc Natl Acad Sci U S A. 2016. PMID: 27001850 Free PMC article.
Deletion of Protein Kinase C λ in POMC Neurons Predisposes to Diet-Induced Obesity.
Dorfman MD, Krull JE, Scarlett JM, Guyenet SJ, Sajan MP, Damian V, Nguyen HT, Leitges M, Morton GJ, Farese RV, Schwartz MW, Thaler JP. Dorfman MD, et al. Among authors: guyenet sj. Diabetes. 2017 Apr;66(4):920-934. doi: 10.2337/db16-0482. Epub 2017 Jan 10. Diabetes. 2017. PMID: 28073831 Free PMC article.
Obesity is associated with hypothalamic injury in rodents and humans.
Thaler JP, Yi CX, Schur EA, Guyenet SJ, Hwang BH, Dietrich MO, Zhao X, Sarruf DA, Izgur V, Maravilla KR, Nguyen HT, Fischer JD, Matsen ME, Wisse BE, Morton GJ, Horvath TL, Baskin DG, Tschöp MH, Schwartz MW. Thaler JP, et al. Among authors: guyenet sj. J Clin Invest. 2012 Jan;122(1):153-62. doi: 10.1172/JCI59660. Epub 2011 Dec 27. J Clin Invest. 2012. PMID: 22201683 Free PMC article.
In uncontrolled diabetes, thyroid hormone and sympathetic activators induce thermogenesis without increasing glucose uptake in brown adipose tissue.
Matsen ME, Thaler JP, Wisse BE, Guyenet SJ, Meek TH, Ogimoto K, Cubelo A, Fischer JD, Kaiyala KJ, Schwartz MW, Morton GJ. Matsen ME, et al. Among authors: guyenet sj. Am J Physiol Endocrinol Metab. 2013 Apr 1;304(7):E734-46. doi: 10.1152/ajpendo.00488.2012. Epub 2013 Feb 5. Am J Physiol Endocrinol Metab. 2013. PMID: 23384771 Free PMC article.
25 results