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Mycobacterium tuberculosis Decaprenylphosphoryl-β-d-ribose Oxidase Inhibitors: Expeditious Reconstruction of Suboptimal Hits into a Series with Potent in Vivo Activity.
Borthwick JA, Alemparte C, Wall I, Whitehurst BC, Argyrou A, Burley G, de Dios-Anton P, Guijarro L, Monteiro MC, Ortega F, Suckling CJ, Pichel JC, Cacho M, Young RJ. Borthwick JA, et al. Among authors: young rj. J Med Chem. 2020 Mar 12;63(5):2557-2576. doi: 10.1021/acs.jmedchem.9b01561. Epub 2020 Jan 22. J Med Chem. 2020. PMID: 31922409 Free article.
Molecular Property Design: Does Everyone Get It?
Leeson PD, Young RJ. Leeson PD, et al. Among authors: young rj. ACS Med Chem Lett. 2015 May 27;6(7):722-5. doi: 10.1021/acsmedchemlett.5b00157. eCollection 2015 Jul 9. ACS Med Chem Lett. 2015. PMID: 26191353 Free PMC article.
Structure- and property-based design of factor Xa inhibitors: pyrrolidin-2-ones with acyclic alanyl amides as P4 motifs.
Young RJ, Campbell M, Borthwick AD, Brown D, Burns-Kurtis CL, Chan C, Convery MA, Crowe MC, Dayal S, Diallo H, Kelly HA, King NP, Kleanthous S, Mason AM, Mordaunt JE, Patel C, Pateman AJ, Senger S, Shah GP, Smith PW, Watson NS, Weston HE, Zhou P. Young RJ, et al. Bioorg Med Chem Lett. 2006 Dec 1;16(23):5953-7. doi: 10.1016/j.bmcl.2006.09.001. Epub 2006 Sep 18. Bioorg Med Chem Lett. 2006. PMID: 16982190
Selective and dual action orally active inhibitors of thrombin and factor Xa.
Young RJ, Brown D, Burns-Kurtis CL, Chan C, Convery MA, Hubbard JA, Kelly HA, Pateman AJ, Patikis A, Senger S, Shah GP, Toomey JR, Watson NS, Zhou P. Young RJ, et al. Bioorg Med Chem Lett. 2007 May 15;17(10):2927-30. doi: 10.1016/j.bmcl.2007.03.080. Epub 2007 Mar 30. Bioorg Med Chem Lett. 2007. PMID: 17420122
Structure and property based design of factor Xa inhibitors: biaryl pyrrolidin-2-ones incorporating basic heterocyclic motifs.
Young RJ, Borthwick AD, Brown D, Burns-Kurtis CL, Campbell M, Chan C, Charbaut M, Convery MA, Diallo H, Hortense E, Irving WR, Kelly HA, King NP, Kleanthous S, Mason AM, Pateman AJ, Patikis AN, Pinto IL, Pollard DR, Senger S, Shah GP, Toomey JR, Watson NS, Weston HE, Zhou P. Young RJ, et al. Bioorg Med Chem Lett. 2008 Jan 1;18(1):28-33. doi: 10.1016/j.bmcl.2007.11.019. Epub 2007 Nov 13. Bioorg Med Chem Lett. 2008. PMID: 18053714
Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with biaryl P4 motifs.
Young RJ, Borthwick AD, Brown D, Burns-Kurtis CL, Campbell M, Chan C, Charbaut M, Chung CW, Convery MA, Kelly HA, Paul King N, Kleanthous S, Mason AM, Pateman AJ, Patikis AN, Pinto IL, Pollard DR, Senger S, Shah GP, Toomey JR, Watson NS, Weston HE. Young RJ, et al. Bioorg Med Chem Lett. 2008 Jan 1;18(1):23-7. doi: 10.1016/j.bmcl.2007.11.023. Epub 2007 Nov 17. Bioorg Med Chem Lett. 2008. PMID: 18054228
744 results