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The long-lasting antidepressant effects of rapastinel (GLYX-13) are associated with a metaplasticity process in the medial prefrontal cortex and hippocampus.
Burgdorf J, Zhang XL, Weiss C, Gross A, Boikess SR, Kroes RA, Khan MA, Burch RM, Rex CS, Disterhoft JF, Stanton PK, Moskal JR. Burgdorf J, et al. Among authors: burch rm. Neuroscience. 2015 Nov 12;308:202-11. doi: 10.1016/j.neuroscience.2015.09.004. Epub 2015 Sep 4. Neuroscience. 2015. PMID: 26343295 Free PMC article.
Rapastinel (GLYX-13) has therapeutic potential for the treatment of post-traumatic stress disorder: Characterization of a NMDA receptor-mediated metaplasticity process in the medial prefrontal cortex of rats.
Burgdorf J, Kroes RA, Zhang XL, Gross AL, Schmidt M, Weiss C, Disterhoft JF, Burch RM, Stanton PK, Moskal JR. Burgdorf J, et al. Among authors: burch rm. Behav Brain Res. 2015 Nov 1;294:177-85. doi: 10.1016/j.bbr.2015.07.039. Epub 2015 Jul 22. Behav Brain Res. 2015. PMID: 26210936 Free PMC article.
GLYX-13, an NMDA receptor glycine site functional partial agonist enhances cognition and produces antidepressant effects without the psychotomimetic side effects of NMDA receptor antagonists.
Moskal JR, Burch R, Burgdorf JS, Kroes RA, Stanton PK, Disterhoft JF, Leander JD. Moskal JR, et al. Expert Opin Investig Drugs. 2014 Feb;23(2):243-54. doi: 10.1517/13543784.2014.852536. Epub 2013 Nov 20. Expert Opin Investig Drugs. 2014. PMID: 24251380 Free PMC article. Review.
Randomized proof of concept trial of GLYX-13, an N-methyl-D-aspartate receptor glycine site partial agonist, in major depressive disorder nonresponsive to a previous antidepressant agent.
Preskorn S, Macaluso M, Mehra DO, Zammit G, Moskal JR, Burch RM; GLYX-13 Clinical Study Group. Preskorn S, et al. Among authors: burch rm. J Psychiatr Pract. 2015 Mar;21(2):140-9. doi: 10.1097/01.pra.0000462606.17725.93. J Psychiatr Pract. 2015. PMID: 25782764 Clinical Trial.
Effects of Rapastinel (Formerly GLYX-13) on Serum Brain-Derived Neurotrophic Factor in Obsessive-Compulsive Disorder.
Linkovski O, Shen H, Zwerling J, Filippou-Frye M, Jo B, Cordell E, Cooper TB, Simpson HB, Burch RM, Moskal JR, Lee F, Rodriguez CI. Linkovski O, et al. Among authors: burch rm. J Clin Psychiatry. 2018 Jan/Feb;79(1):17l11824. doi: 10.4088/JCP.17l11824. J Clin Psychiatry. 2018. PMID: 29505186 Free PMC article. Clinical Trial. No abstract available.
Thiocarbazate building blocks enable the construction of azapeptides for rapid development of therapeutic candidates.
Altiti A, He M, VanPatten S, Cheng KF, Ahmed U, Chiu PY, Mughrabi IT, Jabari BA, Burch RM, Manogue KR, Tracey KJ, Diamond B, Metz CN, Yang H, Hudson LK, Zanos S, Son M, Sherry B, Coleman TR, Al-Abed Y. Altiti A, et al. Among authors: burch rm. Nat Commun. 2022 Nov 28;13(1):7127. doi: 10.1038/s41467-022-34712-9. Nat Commun. 2022. PMID: 36443291 Free PMC article.
Pharmacology of a new cyclic nucleotide phosphodiesterase type 4 inhibitor, V11294.
Gale DD, Hofer P, Spina D, Seeds EA, Banner KH, Harrison S, Douglas G, Matsumoto T, Page CP, Wong RH, Jordan S, Smith F, Banik N, Halushka PV, Cavalla D, Rotshteyn Y, Kyle DJ, Burch RM, Chasin M. Gale DD, et al. Among authors: burch rm. Pulm Pharmacol Ther. 2003;16(2):97-104. doi: 10.1016/S1094-5539(02)00175-X. Pulm Pharmacol Ther. 2003. PMID: 12670778 Review.
103 results