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Estrogen and ERα enhanced β-catenin degradation and suppressed its downstream target genes to block the metastatic function of HA22T hepatocellular carcinoma cells via modulating GSK-3β and β-TrCP expression.
Chen YF, Velmurugan BK, Wang HL, Tu CC, Che RJ, Chen MC, Jen LB, Vishwanadha VP, Hsu HH, Huang CY. Chen YF, et al. Among authors: vishwanadha vp. Environ Toxicol. 2017 Feb;32(2):519-529. doi: 10.1002/tox.22256. Epub 2016 Mar 18. Environ Toxicol. 2017. PMID: 26990689