Lucas CM - Search Results

1

High CIP2A levels correlate with an antiapoptotic phenotype that can be overcome by targeting BCL-XL in chronic myeloid leukemia.

Lucas CM, Milani M, Butterworth M, Carmell N, Scott LJ, Clark RE, Cohen GM, Varadarajan S. Lucas CM, et al. Leukemia. 2016 Jun;30(6):1273-81. doi: 10.1038/leu.2016.42. Epub 2016 Feb 29. Leukemia. 2016. PMID: 26987906 Free PMC article.

2

The role of serial BCR-ABL transcript monitoring in predicting the emergence of BCR-ABL kinase mutations in imatinib-treated patients with chronic myeloid leukemia.

Wang L, Knight K, Lucas C, Clark RE. Wang L, et al. Haematologica. 2006 Feb;91(2):235-9. Haematologica. 2006. PMID: 16461309

3

Effective dasatinib uptake may occur without human organic cation transporter 1 (hOCT1): implications for the treatment of imatinib-resistant chronic myeloid leukemia.

Giannoudis A, Davies A, Lucas CM, Harris RJ, Pirmohamed M, Clark RE. Giannoudis A, et al. Among authors: lucas cm. Blood. 2008 Oct 15;112(8):3348-54. doi: 10.1182/blood-2007-10-116236. Epub 2008 Jul 31. Blood. 2008. PMID: 18669873 Free PMC article.

4

A population study of imatinib in chronic myeloid leukaemia demonstrates lower efficacy than in clinical trials.

Lucas CM, Wang L, Austin GM, Knight K, Watmough SJ, Shwe KH, Dasgupta R, Butt NM, Galvani D, Hoyle CF, Seale JR, Clark RE. Lucas CM, et al. Leukemia. 2008 Oct;22(10):1963-6. doi: 10.1038/leu.2008.225. Epub 2008 Aug 28. Leukemia. 2008. PMID: 18754023 No abstract available.

5

Nilotinib concentration in cell lines and primary CD34(+) chronic myeloid leukemia cells is not mediated by active uptake or efflux by major drug transporters.

Davies A, Jordanides NE, Giannoudis A, Lucas CM, Hatziieremia S, Harris RJ, Jørgensen HG, Holyoake TL, Pirmohamed M, Clark RE, Mountford JC. Davies A, et al. Among authors: lucas cm. Leukemia. 2009 Nov;23(11):1999-2006. doi: 10.1038/leu.2009.166. Epub 2009 Aug 27. Leukemia. 2009. PMID: 19710702 Free article.

6

Chronic myeloid leukemia patients with the e13a2 BCR-ABL fusion transcript have inferior responses to imatinib compared to patients with the e14a2 transcript.

Lucas CM, Harris RJ, Giannoudis A, Davies A, Knight K, Watmough SJ, Wang L, Clark RE. Lucas CM, et al. Haematologica. 2009 Oct;94(10):1362-7. doi: 10.3324/haematol.2009.009134. Epub 2009 Aug 27. Haematologica. 2009. PMID: 19713230 Free PMC article.

7

BCR-ABL1 tyrosine kinase activity at diagnosis, as determined via the pCrkL/CrkL ratio, is predictive of clinical outcome in chronic myeloid leukaemia.

Lucas CM, Harris RJ, Giannoudis A, Knight K, Watmough SJ, Clark RE. Lucas CM, et al. Br J Haematol. 2010 May;149(3):458-60. doi: 10.1111/j.1365-2141.2009.08066.x. Epub 2010 Jan 11. Br J Haematol. 2010. PMID: 20067558 Free article. No abstract available.

8

Cancerous inhibitor of PP2A (CIP2A) at diagnosis of chronic myeloid leukemia is a critical determinant of disease progression.

Lucas CM, Harris RJ, Giannoudis A, Copland M, Slupsky JR, Clark RE. Lucas CM, et al. Blood. 2011 Jun 16;117(24):6660-8. doi: 10.1182/blood-2010-08-304477. Epub 2011 Apr 13. Blood. 2011. PMID: 21490338 Free article.

9

Rapid diagnosis of chronic myeloid leukemia by flow cytometric detection of BCR-ABL1 protein.

Lucas CM, Fagan JL, Carter A, Swale B, Evans C, Clark RE, Harris RJ. Lucas CM, et al. Haematologica. 2011 Jul;96(7):1077-8. doi: 10.3324/haematol.2011.043166. Epub 2011 May 5. Haematologica. 2011. PMID: 21546494 Free PMC article. No abstract available.

10

Assessment of BCR-ABL1 transcript levels at 3 months is the only requirement for predicting outcome for patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors.

Marin D, Ibrahim AR, Lucas C, Gerrard G, Wang L, Szydlo RM, Clark RE, Apperley JF, Milojkovic D, Bua M, Pavlu J, Paliompeis C, Reid A, Rezvani K, Goldman JM, Foroni L. Marin D, et al. J Clin Oncol. 2012 Jan 20;30(3):232-8. doi: 10.1200/JCO.2011.38.6565. Epub 2011 Nov 7. J Clin Oncol. 2012. PMID: 22067393 Free PMC article.

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