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Page 1
Discovery of Novel 3,3-Disubstituted Piperidines as Orally Bioavailable, Potent, and Efficacious HDM2-p53 Inhibitors.
Bogen SL, Pan W, Gibeau CR, Lahue BR, Ma Y, Nair LG, Seigel E, Shipps GW Jr, Tian Y, Wang Y, Lin Y, Liu M, Liu S, Mirza A, Wang X, Lipari P, Seidel-Dugan C, Hicklin DJ, Bishop WR, Rindgen D, Nomeir A, Prosise W, Reichert P, Scapin G, Strickland C, Doll RJ. Bogen SL, et al. Among authors: seidel dugan c. ACS Med Chem Lett. 2016 Jan 20;7(3):324-9. doi: 10.1021/acsmedchemlett.5b00472. eCollection 2016 Mar 10. ACS Med Chem Lett. 2016. PMID: 26985323 Free PMC article.
SCH529074, a small molecule activator of mutant p53, which binds p53 DNA binding domain (DBD), restores growth-suppressive function to mutant p53 and interrupts HDM2-mediated ubiquitination of wild type p53.
Demma M, Maxwell E, Ramos R, Liang L, Li C, Hesk D, Rossman R, Mallams A, Doll R, Liu M, Seidel-Dugan C, Bishop WR, Dasmahapatra B. Demma M, et al. Among authors: seidel dugan c. J Biol Chem. 2010 Apr 2;285(14):10198-212. doi: 10.1074/jbc.M109.083469. Epub 2010 Feb 2. J Biol Chem. 2010. PMID: 20124408 Free PMC article.
mWTX-330, an IL-12 INDUKINE Molecule, Activates and Reshapes Tumor-Infiltrating CD8+ T and NK Cells to Generate Antitumor Immunity.
Nirschl CJ, Brodkin HR, Domonkos C, Dwyer CJ, Hicklin DJ, Ismail N, Seidel-Dugan C, Steiner P, Steuert Z, Sullivan JM, Winston WM, Salmeron A. Nirschl CJ, et al. Among authors: seidel dugan c. Cancer Immunol Res. 2023 Jul 5;11(7):962-977. doi: 10.1158/2326-6066.CIR-22-0705. Cancer Immunol Res. 2023. PMID: 37074216 Free PMC article.
Characterization of ASP8374, a fully-human, antagonistic anti-TIGIT monoclonal antibody.
Shirasuna K, Koelsch G, Seidel-Dugan C, Salmeron A, Steiner P, Winston WM, Brodkin HR, Nirschl CJ, Abbott S, Kinugasa F, Sugahara S, Ohori M, Takeuchi M, Hicklin DJ, Yoshida T. Shirasuna K, et al. Among authors: seidel dugan c. Cancer Treat Res Commun. 2021;28:100433. doi: 10.1016/j.ctarc.2021.100433. Epub 2021 Jul 11. Cancer Treat Res Commun. 2021. PMID: 34273876 Free article.
Evaluating TBK1 as a therapeutic target in cancers with activated IRF3.
Muvaffak A, Pan Q, Yan H, Fernandez R, Lim J, Dolinski B, Nguyen TT, Strack P, Wu S, Chung R, Zhang W, Hulton C, Ripley S, Hirsch H, Nagashima K, Wong KK, Jánne PA, Seidel-Dugan C, Zawel L, Kirschmeier PT, Middleton RE, Morris EJ, Wang Y. Muvaffak A, et al. Among authors: seidel dugan c. Mol Cancer Res. 2014 Jul;12(7):1055-66. doi: 10.1158/1541-7786.MCR-13-0642. Epub 2014 Apr 21. Mol Cancer Res. 2014. PMID: 24752990 Free article.
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