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C/EBPα is required for long-term self-renewal and lineage priming of hematopoietic stem cells and for the maintenance of epigenetic configurations in multipotent progenitors.
Hasemann MS, Lauridsen FK, Waage J, Jakobsen JS, Frank AK, Schuster MB, Rapin N, Bagger FO, Hoppe PS, Schroeder T, Porse BT. Hasemann MS, et al. Among authors: jakobsen js. PLoS Genet. 2014 Jan;10(1):e1004079. doi: 10.1371/journal.pgen.1004079. Epub 2014 Jan 9. PLoS Genet. 2014. PMID: 24415956 Free PMC article.
Transcription factor-driven coordination of cell cycle exit and lineage-specification in vivo during granulocytic differentiation : In memoriam Professor Niels Borregaard.
Theilgaard-Mönch K, Pundhir S, Reckzeh K, Su J, Tapia M, Furtwängler B, Jendholm J, Jakobsen JS, Hasemann MS, Knudsen KJ, Cowland JB, Fossum A, Schoof E, Schuster MB, Porse BT. Theilgaard-Mönch K, et al. Among authors: jakobsen js. Nat Commun. 2022 Jun 23;13(1):3595. doi: 10.1038/s41467-022-31332-1. Nat Commun. 2022. PMID: 35739121 Free PMC article.
UPF2 is a critical regulator of liver development, function and regeneration.
Thoren LA, Nørgaard GA, Weischenfeldt J, Waage J, Jakobsen JS, Damgaard I, Bergström FC, Blom AM, Borup R, Bisgaard HC, Porse BT. Thoren LA, et al. Among authors: jakobsen js. PLoS One. 2010 Jul 19;5(7):e11650. doi: 10.1371/journal.pone.0011650. PLoS One. 2010. PMID: 20657840 Free PMC article.
TGIF1 is a negative regulator of MLL-rearranged acute myeloid leukemia.
Willer A, Jakobsen JS, Ohlsson E, Rapin N, Waage J, Billing M, Bullinger L, Karlsson S, Porse BT. Willer A, et al. Among authors: jakobsen js. Leukemia. 2015 May;29(5):1018-31. doi: 10.1038/leu.2014.307. Epub 2014 Oct 28. Leukemia. 2015. PMID: 25349154
Mutant CEBPA directly drives the expression of the targetable tumor-promoting factor CD73 in AML.
Jakobsen JS, Laursen LG, Schuster MB, Pundhir S, Schoof E, Ge Y, d'Altri T, Vitting-Seerup K, Rapin N, Gentil C, Jendholm J, Theilgaard-Mönch K, Reckzeh K, Bullinger L, Döhner K, Hokland P, Fitzgibbon J, Porse BT. Jakobsen JS, et al. Sci Adv. 2019 Jul 10;5(7):eaaw4304. doi: 10.1126/sciadv.aaw4304. eCollection 2019 Jul. Sci Adv. 2019. PMID: 31309149 Free PMC article.
40 results