Karkhanis A - Search Results

1

Multiple modes of inhibition of human cytochrome P450 2J2 by dronedarone, amiodarone and their active metabolites.

Karkhanis A, Lam HY, Venkatesan G, Koh SK, Chai CL, Zhou L, Hong Y, Kojodjojo P, Chan EC. Karkhanis A, et al. Biochem Pharmacol. 2016 May 1;107:67-80. doi: 10.1016/j.bcp.2016.03.005. Epub 2016 Mar 10. Biochem Pharmacol. 2016. PMID: 26972388

2

Inhibition and inactivation of human CYP2J2: Implications in cardiac pathophysiology and opportunities in cancer therapy.

Karkhanis A, Hong Y, Chan ECY. Karkhanis A, et al. Biochem Pharmacol. 2017 Jul 1;135:12-21. doi: 10.1016/j.bcp.2017.02.017. Epub 2017 Feb 23. Biochem Pharmacol. 2017. PMID: 28237650 Review.

3

Effects of dronedarone, amiodarone and their active metabolites on sequential metabolism of arachidonic acid to epoxyeicosatrienoic and dihydroxyeicosatrienoic acids.

Karkhanis A, Tram NDT, Chan ECY. Karkhanis A, et al. Biochem Pharmacol. 2017 Dec 15;146:188-198. doi: 10.1016/j.bcp.2017.09.012. Epub 2017 Sep 25. Biochem Pharmacol. 2017. PMID: 28958841

4

Dronedarone-Induced Cardiac Mitochondrial Dysfunction and Its Mitigation by Epoxyeicosatrienoic Acids.

Karkhanis A, Leow JWH, Hagen T, Chan ECY. Karkhanis A, et al. Toxicol Sci. 2018 May 1;163(1):79-91. doi: 10.1093/toxsci/kfy011. Toxicol Sci. 2018. PMID: 29385569

5

Preliminary discovery of novel markers for human cell line activation test (h-CLAT).

Karkhanis AV, Chan ECY, Ren EC. Karkhanis AV, et al. Toxicol In Vitro. 2021 Aug;74:105154. doi: 10.1016/j.tiv.2021.105154. Epub 2021 Mar 25. Toxicol In Vitro. 2021. PMID: 33774146

6

Investigations on detoxification mechanisms of novel para-phenylenediamine analogues through N-acetyltransferase 1 (NAT-1).

Venkatesan G, Lim ZC, Karkhanis AV, Neupane YR, Dancik Y, Huang C, Bigliardi P, Pastorin G. Venkatesan G, et al. Arch Toxicol. 2022 Jan;96(1):153-165. doi: 10.1007/s00204-021-03149-2. Epub 2021 Nov 12. Arch Toxicol. 2022. PMID: 34773126

7

Site-directed deuteration of dronedarone preserves cytochrome P4502J2 activity and mitigates its cardiac adverse effects in canine arrhythmic hearts.

Karkhanis AV, Venkatesan G, Kambayashi R, Leow JWH, Han MQ, Izumi-Nakaseko H, Goto A, Pang JKS, Soh BS, Kojodjojo P, Sugiyama A, Chan ECY. Karkhanis AV, et al. Acta Pharm Sin B. 2022 Oct;12(10):3905-3923. doi: 10.1016/j.apsb.2022.03.008. Epub 2022 Mar 16. Acta Pharm Sin B. 2022. PMID: 36213535 Free PMC article.

8

Design, synthesis, molecular docking, and evaluation of sulfonyl quinazoline analogues as promising liver cancer drugs.

Venkatesan G, Ping CY, Chen H, Perumal S, Karkhanis AV, Pastorin G. Venkatesan G, et al. Among authors: karkhanis av. Bioorg Chem. 2024 Dec;153:107777. doi: 10.1016/j.bioorg.2024.107777. Epub 2024 Sep 1. Bioorg Chem. 2024. PMID: 39244968

9

Design, synthesis, molecular modeling and evaluation of 2,4-diaminopyrimidine analogues as promising colorectal cancer drugs.

Venkatesan G, Yong Ping C, Chen H, Srinivasan P, Karkhanis AV, Pastorin G. Venkatesan G, et al. Among authors: karkhanis av. Bioorg Chem. 2024 Dec;153:107854. doi: 10.1016/j.bioorg.2024.107854. Epub 2024 Sep 29. Bioorg Chem. 2024. PMID: 39368143

10

Applications of the Cholesterol Metabolite, 4β-Hydroxycholesterol, as a Sensitive Endogenous Biomarker for Hepatic CYP3A Activity Evaluated within a PBPK Framework.

Karkhanis AV, Harwood MD, Stader F, Bois FY, Neuhoff S. Karkhanis AV, et al. Pharmaceutics. 2024 Sep 30;16(10):1284. doi: 10.3390/pharmaceutics16101284. Pharmaceutics. 2024. PMID: 39458613 Free PMC article.

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