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Peroxisome proliferator-activated receptors (PPARs) have multiple binding points that accommodate ligands in various conformations: phenylpropanoic acid-type PPAR ligands bind to PPAR in different conformations, depending on the subtype.
Kuwabara N, Oyama T, Tomioka D, Ohashi M, Yanagisawa J, Shimizu T, Miyachi H. Kuwabara N, et al. Among authors: shimizu t. J Med Chem. 2012 Jan 26;55(2):893-902. doi: 10.1021/jm2014293. Epub 2012 Jan 10. J Med Chem. 2012. PMID: 22185225
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