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Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models.
Karuppagounder SS, Alim I, Khim SJ, Bourassa MW, Sleiman SF, John R, Thinnes CC, Yeh TL, Demetriades M, Neitemeier S, Cruz D, Gazaryan I, Killilea DW, Morgenstern L, Xi G, Keep RF, Schallert T, Tappero RV, Zhong J, Cho S, Maxfield FR, Holman TR, Culmsee C, Fong GH, Su Y, Ming GL, Song H, Cave JW, Schofield CJ, Colbourne F, Coppola G, Ratan RR. Karuppagounder SS, et al. Among authors: gazaryan i. Sci Transl Med. 2016 Mar 2;8(328):328ra29. doi: 10.1126/scitranslmed.aac6008. Sci Transl Med. 2016. PMID: 26936506 Free PMC article.
Hypoxia-inducible factor prolyl hydroxylases as targets for neuroprotection by "antioxidant" metal chelators: From ferroptosis to stroke.
Speer RE, Karuppagounder SS, Basso M, Sleiman SF, Kumar A, Brand D, Smirnova N, Gazaryan I, Khim SJ, Ratan RR. Speer RE, et al. Among authors: gazaryan i. Free Radic Biol Med. 2013 Sep;62:26-36. doi: 10.1016/j.freeradbiomed.2013.01.026. Epub 2013 Jan 31. Free Radic Biol Med. 2013. PMID: 23376032 Free PMC article. Review.
Antihelminthic benzimidazoles are novel HIF activators that prevent oxidative neuronal death via binding to tubulin.
Aleyasin H, Karuppagounder SS, Kumar A, Sleiman S, Basso M, Ma T, Siddiq A, Chinta SJ, Brochier C, Langley B, Haskew-Layton R, Bane SL, Riggins GJ, Gazaryan I, Starkov AA, Andersen JK, Ratan RR. Aleyasin H, et al. Among authors: gazaryan i. Antioxid Redox Signal. 2015 Jan 10;22(2):121-34. doi: 10.1089/ars.2013.5595. Antioxid Redox Signal. 2015. PMID: 24766300 Free PMC article.
HIF1α stabilization in hypoxia is not oxidant-initiated.
Kumar A, Vaish M, Karuppagounder SS, Gazaryan I, Cave JW, Starkov AA, Anderson ET, Zhang S, Pinto JT, Rountree AM, Wang W, Sweet IR, Ratan RR. Kumar A, et al. Among authors: gazaryan i. Elife. 2021 Oct 1;10:e72873. doi: 10.7554/eLife.72873. Elife. 2021. PMID: 34596045 Free PMC article.
Catalytic mechanism and substrate specificity of HIF prolyl hydroxylases.
Smirnova NA, Hushpulian DM, Speer RE, Gaisina IN, Ratan RR, Gazaryan IG. Smirnova NA, et al. Among authors: gazaryan ig. Biochemistry (Mosc). 2012 Oct;77(10):1108-19. doi: 10.1134/S0006297912100033. Biochemistry (Mosc). 2012. PMID: 23157291 Free article. Review.
Small molecule activation of adaptive gene expression: tilorone or its analogs are novel potent activators of hypoxia inducible factor-1 that provide prophylaxis against stroke and spinal cord injury.
Ratan RR, Siddiq A, Aminova L, Langley B, McConoughey S, Karpisheva K, Lee HH, Carmichael T, Kornblum H, Coppola G, Geschwind DH, Hoke A, Smirnova N, Rink C, Roy S, Sen C, Beattie MS, Hart RP, Grumet M, Sun D, Freeman RS, Semenza GL, Gazaryan I. Ratan RR, et al. Among authors: gazaryan i. Ann N Y Acad Sci. 2008 Dec;1147:383-94. doi: 10.1196/annals.1427.033. Ann N Y Acad Sci. 2008. PMID: 19076458 Free PMC article.
Harnessing hypoxic adaptation to prevent, treat, and repair stroke.
Ratan RR, Siddiq A, Smirnova N, Karpisheva K, Haskew-Layton R, McConoughey S, Langley B, Estevez A, Huerta PT, Volpe B, Roy S, Sen CK, Gazaryan I, Cho S, Fink M, LaManna J. Ratan RR, et al. Among authors: gazaryan i. J Mol Med (Berl). 2007 Dec;85(12):1331-8. doi: 10.1007/s00109-007-0283-1. Epub 2007 Nov 28. J Mol Med (Berl). 2007. PMID: 18043901 Free PMC article. Review.
Activation of Nrf2 and Hypoxic Adaptive Response Contribute to Neuroprotection Elicited by Phenylhydroxamic Acid Selective HDAC6 Inhibitors.
Gaisina IN, Lee SH, Kaidery NA, Ben Aissa M, Ahuja M, Smirnova NN, Wakade S, Gaisin A, Bourassa MW, Ratan RR, Nikulin SV, Poloznikov AA, Thomas B, Thatcher GRJ, Gazaryan IG. Gaisina IN, et al. ACS Chem Neurosci. 2018 May 16;9(5):894-900. doi: 10.1021/acschemneuro.7b00435. Epub 2018 Jan 17. ACS Chem Neurosci. 2018. PMID: 29338172 Free PMC article.
76 results