Hawkins WG - Search Results

1

Membrane-proximal TRAIL species are incapable of inducing short circuit apoptosis signaling: Implications for drug development and basic cytokine biology.

Tatzel K, Kuroki L, Dmitriev I, Kashentseva E, Curiel DT, Goedegebuure SP, Powell MA, Mutch DG, Hawkins WG, Spitzer D. Tatzel K, et al. Among authors: hawkins wg. Sci Rep. 2016 Mar 3;6:22661. doi: 10.1038/srep22661. Sci Rep. 2016. PMID: 26935795 Free PMC article.

2

A genetically encoded multifunctional TRAIL trimer facilitates cell-specific targeting and tumor cell killing.

Spitzer D, McDunn JE, Plambeck-Suess S, Goedegebuure PS, Hotchkiss RS, Hawkins WG. Spitzer D, et al. Among authors: hawkins wg. Mol Cancer Ther. 2010 Jul;9(7):2142-51. doi: 10.1158/1535-7163.MCT-10-0225. Epub 2010 Jun 22. Mol Cancer Ther. 2010. PMID: 20571073 Free PMC article.

3

The novel sigma-2 receptor ligand SW43 stabilizes pancreas cancer progression in combination with gemcitabine.

Hornick JR, Xu J, Vangveravong S, Tu Z, Mitchem JB, Spitzer D, Goedegebuure P, Mach RH, Hawkins WG. Hornick JR, et al. Among authors: hawkins wg. Mol Cancer. 2010 Nov 22;9:298. doi: 10.1186/1476-4598-9-298. Mol Cancer. 2010. PMID: 21092190 Free PMC article.

4

Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site.

Xu J, Zeng C, Chu W, Pan F, Rothfuss JM, Zhang F, Tu Z, Zhou D, Zeng D, Vangveravong S, Johnston F, Spitzer D, Chang KC, Hotchkiss RS, Hawkins WG, Wheeler KT, Mach RH. Xu J, et al. Among authors: hawkins wg. Nat Commun. 2011 Jul 5;2:380. doi: 10.1038/ncomms1386. Nat Commun. 2011. PMID: 21730960 Free PMC article.

5

Use of multifunctional sigma-2 receptor ligand conjugates to trigger cancer-selective cell death signaling.

Spitzer D, Simon PO Jr, Kashiwagi H, Xu J, Zeng C, Vangveravong S, Zhou D, Chang K, McDunn JE, Hornick JR, Goedegebuure P, Hotchkiss RS, Mach RH, Hawkins WG. Spitzer D, et al. Among authors: hawkins wg. Cancer Res. 2012 Jan 1;72(1):201-9. doi: 10.1158/0008-5472.CAN-11-1354. Epub 2011 Nov 7. Cancer Res. 2012. PMID: 22065721 Free PMC article.

6

Lysosomal membrane permeabilization is an early event in Sigma-2 receptor ligand mediated cell death in pancreatic cancer.

Hornick JR, Vangveravong S, Spitzer D, Abate C, Berardi F, Goedegebuure P, Mach RH, Hawkins WG. Hornick JR, et al. Among authors: hawkins wg. J Exp Clin Cancer Res. 2012 May 2;31(1):41. doi: 10.1186/1756-9966-31-41. J Exp Clin Cancer Res. 2012. PMID: 22551149 Free PMC article.

7

Therapeutic targeting of pancreatic cancer utilizing sigma-2 ligands.

Hornick JR, Spitzer D, Goedegebuure P, Mach RH, Hawkins WG. Hornick JR, et al. Among authors: hawkins wg. Surgery. 2012 Sep;152(3 Suppl 1):S152-6. doi: 10.1016/j.surg.2012.05.014. Epub 2012 Jul 3. Surgery. 2012. PMID: 22763259 Free PMC article. Review.

8

A Study of Zoledronic Acid as Neo-Adjuvant, Perioperative Therapy in Patients with Resectable Pancreatic Ductal Adenocarcinoma.

Sanford DE, Porembka MR, Panni RZ, Mitchem JB, Belt BA, Plambeck-Suess SM, Lin G, Denardo DG, Fields RC, Hawkins WG, Strasberg SM, Lockhart AC, Wang-Gillam A, Goedegebuure SP, Linehan DC. Sanford DE, et al. Among authors: hawkins wg. J Cancer Ther. 2013 May;4(3):797-803. doi: 10.4236/jct.2013.43096. J Cancer Ther. 2013. PMID: 24089656 Free PMC article.

9

Novel treatment option for MUC16-positive malignancies with the targeted TRAIL-based fusion protein Meso-TR3.

Garg G, Gibbs J, Belt B, Powell MA, Mutch DG, Goedegebuure P, Collins L, Piwnica-Worms D, Hawkins WG, Spitzer D. Garg G, et al. Among authors: hawkins wg. BMC Cancer. 2014 Jan 21;14:35. doi: 10.1186/1471-2407-14-35. BMC Cancer. 2014. PMID: 24447304 Free PMC article.

10

Conjugation to a SMAC mimetic potentiates sigma-2 ligand induced tumor cell death in ovarian cancer.

Garg G, Vangveravong S, Zeng C, Collins L, Hornick M, Hashim Y, Piwnica-Worms D, Powell MA, Mutch DG, Mach RH, Hawkins WG, Spitzer D. Garg G, et al. Among authors: hawkins wg. Mol Cancer. 2014 Mar 7;13:50. doi: 10.1186/1476-4598-13-50. Mol Cancer. 2014. PMID: 24602489 Free PMC article.

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