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The redox environment triggers conformational changes and aggregation of hIAPP in Type II Diabetes.
Rodriguez Camargo DC, Tripsianes K, Buday K, Franko A, Göbl C, Hartlmüller C, Sarkar R, Aichler M, Mettenleiter G, Schulz M, Böddrich A, Erck C, Martens H, Walch AK, Madl T, Wanker EE, Conrad M, de Angelis MH, Reif B. Rodriguez Camargo DC, et al. Among authors: wanker ee. Sci Rep. 2017 Mar 13;7:44041. doi: 10.1038/srep44041. Sci Rep. 2017. PMID: 28287098 Free PMC article.
Epigallocatechin gallate (EGCG) reduces the intensity of pancreatic amyloid fibrils in human islet amyloid polypeptide (hIAPP) transgenic mice.
Franko A, Rodriguez Camargo DC, Böddrich A, Garg D, Rodriguez Camargo A, Rathkolb B, Janik D, Aichler M, Feuchtinger A, Neff F, Fuchs H, Wanker EE, Reif B, Häring HU, Peter A, Hrabě de Angelis M. Franko A, et al. Among authors: wanker ee. Sci Rep. 2018 Jan 18;8(1):1116. doi: 10.1038/s41598-017-18807-8. Sci Rep. 2018. PMID: 29348618 Free PMC article.
Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models.
Ehrnhoefer DE, Duennwald M, Markovic P, Wacker JL, Engemann S, Roark M, Legleiter J, Marsh JL, Thompson LM, Lindquist S, Muchowski PJ, Wanker EE. Ehrnhoefer DE, et al. Among authors: wanker ee. Hum Mol Genet. 2006 Sep 15;15(18):2743-51. doi: 10.1093/hmg/ddl210. Epub 2006 Aug 7. Hum Mol Genet. 2006. PMID: 16893904 Free article.
193 results