Bershtein S - Search Results

1

Biophysical principles predict fitness landscapes of drug resistance.

Rodrigues JV, Bershtein S, Li A, Lozovsky ER, Hartl DL, Shakhnovich EI. Rodrigues JV, et al. Among authors: bershtein s. Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):E1470-8. doi: 10.1073/pnas.1601441113. Epub 2016 Feb 29. Proc Natl Acad Sci U S A. 2016. PMID: 26929328 Free PMC article.

2

Soluble oligomerization provides a beneficial fitness effect on destabilizing mutations.

Bershtein S, Mu W, Shakhnovich EI. Bershtein S, et al. Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):4857-62. doi: 10.1073/pnas.1118157109. Epub 2012 Mar 12. Proc Natl Acad Sci U S A. 2012. PMID: 22411825 Free PMC article.

3

Protein quality control acts on folding intermediates to shape the effects of mutations on organismal fitness.

Bershtein S, Mu W, Serohijos AW, Zhou J, Shakhnovich EI. Bershtein S, et al. Mol Cell. 2013 Jan 10;49(1):133-44. doi: 10.1016/j.molcel.2012.11.004. Epub 2012 Dec 6. Mol Cell. 2013. PMID: 23219534 Free PMC article.

4

Systems-level response to point mutations in a core metabolic enzyme modulates genotype-phenotype relationship.

Bershtein S, Choi JM, Bhattacharyya S, Budnik B, Shakhnovich E. Bershtein S, et al. Cell Rep. 2015 Apr 28;11(4):645-56. doi: 10.1016/j.celrep.2015.03.051. Epub 2015 Apr 16. Cell Rep. 2015. PMID: 25892240 Free PMC article.

5

Delayed commitment to evolutionary fate in antibiotic resistance fitness landscapes.

Palmer AC, Toprak E, Baym M, Kim S, Veres A, Bershtein S, Kishony R. Palmer AC, et al. Among authors: bershtein s. Nat Commun. 2015 Jun 10;6:7385. doi: 10.1038/ncomms8385. Nat Commun. 2015. PMID: 26060115 Free PMC article.

6

Protein Homeostasis Imposes a Barrier on Functional Integration of Horizontally Transferred Genes in Bacteria.

Bershtein S, Serohijos AW, Bhattacharyya S, Manhart M, Choi JM, Mu W, Zhou J, Shakhnovich EI. Bershtein S, et al. PLoS Genet. 2015 Oct 20;11(10):e1005612. doi: 10.1371/journal.pgen.1005612. eCollection 2015 Oct. PLoS Genet. 2015. PMID: 26484862 Free PMC article.

7

Bridging the physical scales in evolutionary biology: from protein sequence space to fitness of organisms and populations.

Bershtein S, Serohijos AW, Shakhnovich EI. Bershtein S, et al. Curr Opin Struct Biol. 2017 Feb;42:31-40. doi: 10.1016/j.sbi.2016.10.013. Epub 2016 Oct 31. Curr Opin Struct Biol. 2017. PMID: 27810574 Free PMC article. Review.

8

Transient protein-protein interactions perturb E. coli metabolome and cause gene dosage toxicity.

Bhattacharyya S, Bershtein S, Yan J, Argun T, Gilson AI, Trauger SA, Shakhnovich EI. Bhattacharyya S, et al. Among authors: bershtein s. Elife. 2016 Dec 10;5:e20309. doi: 10.7554/eLife.20309. Elife. 2016. PMID: 27938662 Free PMC article.

9

Gene Dosage Experiments in Enterobacteriaceae Using Arabinose-regulated Promoters.

Bhattacharyya S, Bershtein S, Shakhnovich EI. Bhattacharyya S, et al. Among authors: bershtein s. Bio Protoc. 2014 Jul 20;7(14):e2396. doi: 10.21769/BioProtoc.2396. Bio Protoc. 2014. PMID: 29170750 Free PMC article.

10

Metabolic response to point mutations reveals principles of modulation of in vivo enzyme activity and phenotype.

Bhattacharyya S, Bershtein S, Adkar BV, Woodard J, Shakhnovich EI. Bhattacharyya S, et al. Among authors: bershtein s. Mol Syst Biol. 2021 Jun;17(6):e10200. doi: 10.15252/msb.202110200. Mol Syst Biol. 2021. PMID: 34180142 Free PMC article.

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