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A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice.
Quach C, Song Y, Guo H, Li S, Maazi H, Fung M, Sands N, O'Connell D, Restrepo-Vassalli S, Chai B, Nemecio D, Punj V, Akbari O, Idos GE, Mumenthaler SM, Wu N, Martin SE, Hagiya A, Hicks J, Cui H, Liang C. Quach C, et al. Among authors: liang c. Nat Commun. 2019 Dec 12;10(1):5681. doi: 10.1038/s41467-019-13475-w. Nat Commun. 2019. PMID: 31831743 Free PMC article.
PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex.
He S, Ni D, Ma B, Lee JH, Zhang T, Ghozalli I, Pirooz SD, Zhao Z, Bharatham N, Li B, Oh S, Lee WH, Takahashi Y, Wang HG, Minassian A, Feng P, Deretic V, Pepperkok R, Tagaya M, Yoon HS, Liang C. He S, et al. Among authors: liang c. Nat Cell Biol. 2013 Oct;15(10):1206-1219. doi: 10.1038/ncb2848. Epub 2013 Sep 22. Nat Cell Biol. 2013. PMID: 24056303 Free PMC article.
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