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CSAHi study: Validation of multi-electrode array systems (MEA60/2100) for prediction of drug-induced proarrhythmia using human iPS cell-derived cardiomyocytes -assessment of inter-facility and cells lot-to-lot-variability.
Nozaki Y, Honda Y, Watanabe H, Saiki S, Koyabu K, Itoh T, Nagasawa C, Nakamori C, Nakayama C, Iwasaki H, Suzuki S, Washio I, Takahashi E, Miyamoto K, Yamanishi A, Endo H, Shinozaki J, Nogawa H, Kunimatsu T. Nozaki Y, et al. Among authors: koyabu k. Regul Toxicol Pharmacol. 2016 Jun;77:75-86. doi: 10.1016/j.yrtph.2016.02.007. Epub 2016 Feb 13. Regul Toxicol Pharmacol. 2016. PMID: 26884090
CSAHi study-2: Validation of multi-electrode array systems (MEA60/2100) for prediction of drug-induced proarrhythmia using human iPS cell-derived cardiomyocytes: Assessment of reference compounds and comparison with non-clinical studies and clinical information.
Nozaki Y, Honda Y, Watanabe H, Saiki S, Koyabu K, Itoh T, Nagasawa C, Nakamori C, Nakayama C, Iwasaki H, Suzuki S, Tanaka K, Takahashi E, Miyamoto K, Morimura K, Yamanishi A, Endo H, Shinozaki J, Nogawa H, Shinozawa T, Saito F, Kunimatsu T. Nozaki Y, et al. Among authors: koyabu k. Regul Toxicol Pharmacol. 2017 Aug;88:238-251. doi: 10.1016/j.yrtph.2017.06.006. Epub 2017 Jun 17. Regul Toxicol Pharmacol. 2017. PMID: 28634147
Distinct relations among plasma concentrations required for different pharmacological effects in oxycodone, morphine, and fentanyl.
Nakamura A, Hasegawa M, Ito H, Minami K, Koike K, Habu-Tomita N, Nanba K, Hamaguchi K, Noshi E, Hashimoto H, Nishino I, Okabayashi Y, Koyabu K, Kihara T, Iwamoto Y, Inoue Y, Narita M, Suzuki T, Kato A. Nakamura A, et al. Among authors: koyabu k. J Pain Palliat Care Pharmacother. 2011;25(4):318-34. doi: 10.3109/15360288.2011.620689. J Pain Palliat Care Pharmacother. 2011. PMID: 22126163
Rational Design of Novel 1,3-Oxazine Based β-Secretase (BACE1) Inhibitors: Incorporation of a Double Bond To Reduce P-gp Efflux Leading to Robust Aβ Reduction in the Brain.
Fuchino K, Mitsuoka Y, Masui M, Kurose N, Yoshida S, Komano K, Yamamoto T, Ogawa M, Unemura C, Hosono M, Ito H, Sakaguchi G, Ando S, Ohnishi S, Kido Y, Fukushima T, Miyajima H, Hiroyama S, Koyabu K, Dhuyvetter D, Borghys H, Gijsen HJM, Yamano Y, Iso Y, Kusakabe KI. Fuchino K, et al. Among authors: koyabu k. J Med Chem. 2018 Jun 28;61(12):5122-5137. doi: 10.1021/acs.jmedchem.8b00002. Epub 2018 May 23. J Med Chem. 2018. PMID: 29733614
Alignment of optical axes by using electrostatic force.
Kikuya Y, Hirano M, Koyabu K, Ohira F. Kikuya Y, et al. Among authors: koyabu k. Opt Lett. 1993 Jun 1;18(11):864. doi: 10.1364/ol.18.000864. Opt Lett. 1993. PMID: 19802297 No abstract available.