Nabhan JF - Search Results

1

Intrathecal delivery of frataxin mRNA encapsulated in lipid nanoparticles to dorsal root ganglia as a potential therapeutic for Friedreich's ataxia.

Nabhan JF, Wood KM, Rao VP, Morin J, Bhamidipaty S, LaBranche TP, Gooch RL, Bozal F, Bulawa CE, Guild BC. Nabhan JF, et al. Sci Rep. 2016 Feb 17;6:20019. doi: 10.1038/srep20019. Sci Rep. 2016. PMID: 26883577 Free PMC article.

2

Perturbation of cellular proteostasis networks identifies pathways that modulate precursor and intermediate but not mature levels of frataxin.

Nabhan JF, Gooch RL, Piatnitski Chekler EL, Pierce B, Bulawa CE. Nabhan JF, et al. Sci Rep. 2015 Dec 16;5:18251. doi: 10.1038/srep18251. Sci Rep. 2015. PMID: 26671574 Free PMC article.

3

Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism.

Fox NG, Yu X, Feng X, Bailey HJ, Martelli A, Nabhan JF, Strain-Damerell C, Bulawa C, Yue WW, Han S. Fox NG, et al. Among authors: nabhan jf. Nat Commun. 2019 May 17;10(1):2210. doi: 10.1038/s41467-019-09989-y. Nat Commun. 2019. PMID: 31101807 Free PMC article.

4

Zinc(II) binding on human wild-type ISCU and Met140 variants modulates NFS1 desulfurase activity.

Fox NG, Martelli A, Nabhan JF, Janz J, Borkowska O, Bulawa C, Yue WW. Fox NG, et al. Among authors: nabhan jf. Biochimie. 2018 Sep;152:211-218. doi: 10.1016/j.biochi.2018.07.012. Epub 2018 Jul 20. Biochimie. 2018. PMID: 30031876 Free PMC article.

5

4'-Phosphopantetheine and long acyl chain-dependent interactions are integral to human mitochondrial acyl carrier protein function.

Majmudar JD, Feng X, Fox NG, Nabhan JF, Towle T, Ma T, Gooch R, Bulawa C, Yue WW, Martelli A. Majmudar JD, et al. Among authors: nabhan jf. Medchemcomm. 2019 Jan 8;10(2):209-220. doi: 10.1039/c8md00489g. eCollection 2019 Feb 1. Medchemcomm. 2019. PMID: 30881609 Free PMC article.

6

Correlation between frataxin expression and contractility revealed by in vitro Friedreich's ataxia cardiac tissue models engineered from human pluripotent stem cells.

Wong AO, Wong G, Shen M, Chow MZ, Tse WW, Gurung B, Mak SY, Lieu DK, Costa KD, Chan CW, Martelli A, Nabhan JF, Li RA. Wong AO, et al. Among authors: nabhan jf. Stem Cell Res Ther. 2019 Jul 8;10(1):203. doi: 10.1186/s13287-019-1305-y. Stem Cell Res Ther. 2019. PMID: 31286988 Free PMC article.

7

Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA).

Gopalsamy A, Narayanan A, Liu S, Parikh MD, Kyne RE Jr, Fadeyi O, Tones MA, Cherry JJ, Nabhan JF, LaRosa G, Petersen DN, Menard C, Foley TL, Noell S, Ren Y, Loria PM, Maglich-Goodwin J, Rong H, Jones LH. Gopalsamy A, et al. Among authors: nabhan jf. J Med Chem. 2017 Apr 13;60(7):3094-3108. doi: 10.1021/acs.jmedchem.7b00124. Epub 2017 Mar 16. J Med Chem. 2017. PMID: 28257199

8

Arrestin domain-containing protein 3 recruits the NEDD4 E3 ligase to mediate ubiquitination of the beta2-adrenergic receptor.

Nabhan JF, Pan H, Lu Q. Nabhan JF, et al. EMBO Rep. 2010 Aug;11(8):605-11. doi: 10.1038/embor.2010.80. Epub 2010 Jun 18. EMBO Rep. 2010. PMID: 20559325 Free PMC article.

9

A novel EST-derived RNAi screen reveals a critical role for farnesyl diphosphate synthase in β2-adrenergic receptor internalization and down-regulation.

Jiang X, Pan H, Nabhan JF, Krishnan R, Koziol-White C, Panettieri RA, Lu Q. Jiang X, et al. Among authors: nabhan jf. FASEB J. 2012 May;26(5):1995-2007. doi: 10.1096/fj.11-193870. Epub 2012 Jan 25. FASEB J. 2012. PMID: 22278941 Free PMC article.

10

Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein.

Nabhan JF, Hu R, Oh RS, Cohen SN, Lu Q. Nabhan JF, et al. Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4146-51. doi: 10.1073/pnas.1200448109. Epub 2012 Feb 6. Proc Natl Acad Sci U S A. 2012. PMID: 22315426 Free PMC article.

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