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Extending (Q)SARs to incorporate proprietary knowledge for regulatory purposes: A case study using aromatic amine mutagenicity.
Ahlberg E, Amberg A, Beilke LD, Bower D, Cross KP, Custer L, Ford KA, Van Gompel J, Harvey J, Honma M, Jolly R, Joossens E, Kemper RA, Kenyon M, Kruhlak N, Kuhnke L, Leavitt P, Naven R, Neilan C, Quigley DP, Shuey D, Spirkl HP, Stavitskaya L, Teasdale A, White A, Wichard J, Zwickl C, Myatt GJ. Ahlberg E, et al. Among authors: kruhlak n. Regul Toxicol Pharmacol. 2016 Jun;77:1-12. doi: 10.1016/j.yrtph.2016.02.003. Epub 2016 Feb 13. Regul Toxicol Pharmacol. 2016. PMID: 26879463
An analysis of genetic toxicity, reproductive and developmental toxicity, and carcinogenicity data: II. Identification of genotoxicants, reprotoxicants, and carcinogens using in silico methods.
Matthews EJ, Kruhlak NL, Cimino MC, Benz RD, Contrera JF. Matthews EJ, et al. Regul Toxicol Pharmacol. 2006 Mar;44(2):97-110. doi: 10.1016/j.yrtph.2005.10.004. Epub 2005 Dec 13. Regul Toxicol Pharmacol. 2006. PMID: 16352383
We constructed 21 modules using the MC4PC program including 13 of 14 (11 genetox and 3 reprotox) tests that we found correlated with results of rodent carcinogenicity bioassays (rcbioassays) [Matthews, E.J., Kruhlak, N.L., Cimino, M.C., Benz, R.D., Contrera, J.F., 2 …
We constructed 21 modules using the MC4PC program including 13 of 14 (11 genetox and 3 reprotox) tests that we found correlated with results …
Identification of structure-activity relationships for adverse effects of pharmaceuticals in humans: Part C: use of QSAR and an expert system for the estimation of the mechanism of action of drug-induced hepatobiliary and urinary tract toxicities.
Matthews EJ, Kruhlak NL, Benz RD, Aragonés Sabaté D, Marchant CA, Contrera JF. Matthews EJ, et al. Regul Toxicol Pharmacol. 2009 Jun;54(1):43-65. doi: 10.1016/j.yrtph.2009.01.007. Regul Toxicol Pharmacol. 2009. PMID: 19422100
48 results