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2,125 results

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Page 1
The discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivity.
Newton R, Bowler KA, Burns EM, Chapman PJ, Fairweather EE, Fritzl SJR, Goldberg KM, Hamilton NM, Holt SV, Hopkins GV, Jones SD, Jordan AM, Lyons AJ, Nikki March H, McDonald NQ, Maguire LA, Mould DP, Purkiss AG, Small HF, Stowell AIJ, Thomson GJ, Waddell ID, Waszkowycz B, Watson AJ, Ogilvie DJ. Newton R, et al. Eur J Med Chem. 2016 Apr 13;112:20-32. doi: 10.1016/j.ejmech.2016.01.039. Epub 2016 Jan 29. Eur J Med Chem. 2016. PMID: 26874741 Free PMC article.
Anilinoquinazoline inhibitors of the RET kinase domain-Elaboration of the 7-position.
Jordan AM, Begum H, Fairweather E, Fritzl S, Goldberg K, Hopkins GV, Hamilton NM, Lyons AJ, March HN, Newton R, Small HF, Vishwanath S, Waddell ID, Waszkowycz B, Watson AJ, Ogilvie DJ. Jordan AM, et al. Among authors: newton r. Bioorg Med Chem Lett. 2016 Jun 1;26(11):2724-9. doi: 10.1016/j.bmcl.2016.03.100. Epub 2016 Mar 30. Bioorg Med Chem Lett. 2016. PMID: 27086121 Free PMC article.
Discovery and Optimization of wt-RET/KDR-Selective Inhibitors of RETV804M Kinase.
Newton R, Waszkowycz B, Seewooruthun C, Burschowsky D, Richards M, Hitchin S, Begum H, Watson A, French E, Hamilton N, Jones S, Lin LY, Waddell I, Echalier A, Bayliss R, Jordan AM, Ogilvie D. Newton R, et al. ACS Med Chem Lett. 2020 Feb 28;11(4):497-505. doi: 10.1021/acsmedchemlett.9b00615. eCollection 2020 Apr 9. ACS Med Chem Lett. 2020. PMID: 32292556 Free PMC article.
Identification of selective inhibitors of RET and comparison with current clinical candidates through development and validation of a robust screening cascade.
Watson AJ, Hopkins GV, Hitchin S, Begum H, Jones S, Jordan A, Holt S, March HN, Newton R, Small H, Stowell A, Waddell ID, Waszkowycz B, Ogilvie DJ. Watson AJ, et al. Among authors: newton r. F1000Res. 2016 May 26;5:1005. doi: 10.12688/f1000research.8724.2. eCollection 2016. F1000Res. 2016. PMID: 27429741 Free PMC article.
Multi-methods process evaluation of the SToP (See, Treat, Prevent) trial: a cluster randomised, stepped wedge trial to support healthy skin.
Thomas HMM, Mullane M, Enkel SL, McRae T, Amgarth-Duff I, Carapetis JR, Coffin J, Christophers R, Famlonga R, Jacky J, Jones M, Marsh J, McIntosh K, O'Donnell V, Pan E, Pearson G, Sibosado S, Smith B, Snelling T, Steer A, Tong SYC, Walker R, Whelan A, White K, Wright E, Bowen AC; SToP (See, Treat, Prevent skin sores and scabies) Trial. Thomas HMM, et al. EClinicalMedicine. 2024 Oct 9;77:102793. doi: 10.1016/j.eclinm.2024.102793. eCollection 2024 Nov. EClinicalMedicine. 2024. PMID: 39649132 Free PMC article.
Meeting Aerobic Physical Activity Guidelines and Associations With Physical Fitness in Men With Metastatic Prostate Cancer: Baseline Results of the Multicentre INTERVAL-GAP4 Trial.
Umlauff L, Kenfield SA, Newton RU, Hart NH, Saad F, Courneya KS, Greenwood R, Bloch W; INTERVAL‐GAP4 Steering Committee/Coordinating Centres Members/Protocol Development Working Group Members; Schumann M. Umlauff L, et al. Among authors: newton ru. Cancer Med. 2024 Dec;13(23):e70261. doi: 10.1002/cam4.70261. Cancer Med. 2024. PMID: 39632499 Free PMC article.
Effects of resistance training vs high intensity interval training on body composition, muscle strength, cardiorespiratory fitness, and quality of life in survivors of breast cancer: a randomized trial.
Bettariga F, Taaffe DR, Crespo-Garcia C, Clay TD, Galvão DA, Newton RU. Bettariga F, et al. Among authors: newton ru. Breast Cancer Res Treat. 2024 Nov 18. doi: 10.1007/s10549-024-07559-5. Online ahead of print. Breast Cancer Res Treat. 2024. PMID: 39557768
Health Literacy Directed Weight Loss Intervention in Primary Care Clinics.
Davis T, Arnold C, Zhang D, Martin CK, Newton RL Jr, Myers C, Denstel KD, Mire EF, Höchsmann C, Apolzan J, Katzmarzyk PT; PROPEL Research Group. Davis T, et al. Among authors: newton rl jr. Health Lit Res Pract. 2024 Oct;8(4):e204-e211. doi: 10.3928/24748307-20240618-01. Epub 2024 Nov 1. Health Lit Res Pract. 2024. PMID: 39510531 Free PMC article. Clinical Trial.
2,125 results